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Interleukin-17A Contributes to the Control of Streptococcus pyogenes Colonization and Inflammation of the Female Genital Tract.

Publication ,  Journal Article
Carey, AJ; Weinberg, JB; Dawid, SR; Venturini, C; Lam, AK; Nizet, V; Caparon, MG; Walker, MJ; Watson, ME; Ulett, GC
Published in: Sci Rep
May 31, 2016

Postpartum women are at increased risk of developing puerperal sepsis caused by group A Streptococcus (GAS). Specific GAS serotypes, including M1 and M28, are more commonly associated with puerperal sepsis. However, the mechanisms of GAS genital tract infection are not well understood. We utilized a murine genital tract carriage model to demonstrate that M1 and M28 GAS colonization triggers TNF-α, IL-1β, and IL-17A production in the female genital tract. GAS-induced IL-17A significantly influences streptococcal carriage and alters local inflammatory responses in two genetically distinct inbred strains of mice. An absence of IL-17A or the IL-1 receptor was associated with reduced neutrophil recruitment to the site of infection; and clearance of GAS was significantly attenuated in IL-17A(-/-) mice and Rag1(-/-) mice (that lack mature lymphocytes) but not in mice deficient for the IL-1 receptor. Together, these findings support a role for IL-17A in contributing to the control of streptococcal mucosal colonization and provide new insight into the inflammatory mediators regulating host-pathogen interactions in the female genital tract.

Duke Scholars

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

May 31, 2016

Volume

6

Start / End Page

26836

Location

England

Related Subject Headings

  • Vagina
  • Streptococcus pyogenes
  • Streptococcal Infections
  • Reproductive Tract Infections
  • Neutrophil Infiltration
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Lymphocytes
  • Interleukin-17
  • Inflammation Mediators
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Carey, A. J., Weinberg, J. B., Dawid, S. R., Venturini, C., Lam, A. K., Nizet, V., … Ulett, G. C. (2016). Interleukin-17A Contributes to the Control of Streptococcus pyogenes Colonization and Inflammation of the Female Genital Tract. Sci Rep, 6, 26836. https://doi.org/10.1038/srep26836
Carey, Alison J., Jason B. Weinberg, Suzanne R. Dawid, Carola Venturini, Alfred K. Lam, Victor Nizet, Michael G. Caparon, Mark J. Walker, Michael E. Watson, and Glen C. Ulett. “Interleukin-17A Contributes to the Control of Streptococcus pyogenes Colonization and Inflammation of the Female Genital Tract.Sci Rep 6 (May 31, 2016): 26836. https://doi.org/10.1038/srep26836.
Carey AJ, Weinberg JB, Dawid SR, Venturini C, Lam AK, Nizet V, et al. Interleukin-17A Contributes to the Control of Streptococcus pyogenes Colonization and Inflammation of the Female Genital Tract. Sci Rep. 2016 May 31;6:26836.
Carey, Alison J., et al. “Interleukin-17A Contributes to the Control of Streptococcus pyogenes Colonization and Inflammation of the Female Genital Tract.Sci Rep, vol. 6, May 2016, p. 26836. Pubmed, doi:10.1038/srep26836.
Carey AJ, Weinberg JB, Dawid SR, Venturini C, Lam AK, Nizet V, Caparon MG, Walker MJ, Watson ME, Ulett GC. Interleukin-17A Contributes to the Control of Streptococcus pyogenes Colonization and Inflammation of the Female Genital Tract. Sci Rep. 2016 May 31;6:26836.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

May 31, 2016

Volume

6

Start / End Page

26836

Location

England

Related Subject Headings

  • Vagina
  • Streptococcus pyogenes
  • Streptococcal Infections
  • Reproductive Tract Infections
  • Neutrophil Infiltration
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Lymphocytes
  • Interleukin-17
  • Inflammation Mediators