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Prostaglandin E2 induction during mouse adenovirus type 1 respiratory infection regulates inflammatory mediator generation but does not affect viral pathogenesis.

Publication ,  Journal Article
McCarthy, MK; Levine, RE; Procario, MC; McDonnell, PJ; Zhu, L; Mancuso, P; Crofford, LJ; Aronoff, DM; Weinberg, JB
Published in: PLoS One
2013

Respiratory viruses cause substantial disease and are a significant healthcare burden. Virus-induced inflammation can be detrimental to the host, causing symptoms during acute infection and leading to damage that contributes to long-term residual lung disease. Prostaglandin E2 (PGE2) is a lipid mediator that is increased in response to many viral infections, and inhibition of PGE2 production during respiratory viral infection often leads to a decreased inflammatory response. We tested the hypothesis that PGE2 promotes inflammatory responses to mouse adenovirus type 1 (MAV-1) respiratory infection. Acute MAV-1 infection increased COX-2 expression and PGE2 production in wild type mice. Deficiency of the E prostanoid 2 receptor had no apparent effect on MAV-1 pathogenesis. Virus-induced induction of PGE2, IFN-γ, CXCL1, and CCL5 was reduced in mice deficient in microsomal PGE synthase-1 (mPGES-1(-/-) mice). However, there were no differences between mPGES-1(+/+) and mPGES-1(-/-) mice in viral replication, recruitment of leukocytes to airways or lung inflammation. Infection of both mPGES‑1(+/+) and mPGES-1(-/-) mice led to protection against reinfection. Thus, while PGE2 promotes the expression of a variety of cytokines in response to acute MAV-1 infection, PGE2 synthesis does not appear to be essential for generating pulmonary immunity.

Duke Scholars

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2013

Volume

8

Issue

10

Start / End Page

e77628

Location

United States

Related Subject Headings

  • Virus Replication
  • Respiratory Tract Infections
  • Real-Time Polymerase Chain Reaction
  • Mice, Mutant Strains
  • Mice
  • Male
  • Interferon-gamma
  • General Science & Technology
  • Dinoprostone
  • Chemokine CXCL1
 

Citation

APA
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ICMJE
MLA
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McCarthy, M. K., Levine, R. E., Procario, M. C., McDonnell, P. J., Zhu, L., Mancuso, P., … Weinberg, J. B. (2013). Prostaglandin E2 induction during mouse adenovirus type 1 respiratory infection regulates inflammatory mediator generation but does not affect viral pathogenesis. PLoS One, 8(10), e77628. https://doi.org/10.1371/journal.pone.0077628
McCarthy, Mary K., Rachael E. Levine, Megan C. Procario, Peter J. McDonnell, Lingqiao Zhu, Peter Mancuso, Leslie J. Crofford, David M. Aronoff, and Jason B. Weinberg. “Prostaglandin E2 induction during mouse adenovirus type 1 respiratory infection regulates inflammatory mediator generation but does not affect viral pathogenesis.PLoS One 8, no. 10 (2013): e77628. https://doi.org/10.1371/journal.pone.0077628.
McCarthy, Mary K., et al. “Prostaglandin E2 induction during mouse adenovirus type 1 respiratory infection regulates inflammatory mediator generation but does not affect viral pathogenesis.PLoS One, vol. 8, no. 10, 2013, p. e77628. Pubmed, doi:10.1371/journal.pone.0077628.
McCarthy MK, Levine RE, Procario MC, McDonnell PJ, Zhu L, Mancuso P, Crofford LJ, Aronoff DM, Weinberg JB. Prostaglandin E2 induction during mouse adenovirus type 1 respiratory infection regulates inflammatory mediator generation but does not affect viral pathogenesis. PLoS One. 2013;8(10):e77628.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2013

Volume

8

Issue

10

Start / End Page

e77628

Location

United States

Related Subject Headings

  • Virus Replication
  • Respiratory Tract Infections
  • Real-Time Polymerase Chain Reaction
  • Mice, Mutant Strains
  • Mice
  • Male
  • Interferon-gamma
  • General Science & Technology
  • Dinoprostone
  • Chemokine CXCL1