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Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE₂.

Publication ,  Journal Article
Kim, Y-G; Udayanga, KGS; Totsuka, N; Weinberg, JB; Núñez, G; Shibuya, A
Published in: Cell Host Microbe
January 15, 2014

Although imbalances in gut microbiota composition, or "dysbiosis," are associated with many diseases, the effects of gut dysbiosis on host systemic physiology are less well characterized. We report that gut dysbiosis induced by antibiotic (Abx) treatment promotes allergic airway inflammation by shifting macrophage polarization in the lung toward the alternatively activated M2 phenotype. Adoptive transfer of alveolar macrophages derived from Abx-treated mice was sufficient to increase allergic airway inflammation. Abx treatment resulted in the overgrowth of a commensal fungal Candida species in the gut and increased plasma concentrations of prostaglandin E₂ (PGE₂), which induced M2 macrophage polarization in the lung. Suppression of PGE₂ synthesis by the cyclooxygenase inhibitors aspirin and celecoxib suppressed M2 macrophage polarization and decreased allergic airway inflammatory cell infiltration in Abx-treated mice. Thus, Abx treatment can cause overgrowth of particular fungal species in the gut and promote M2 macrophage activation at distant sites to influence systemic responses including allergic inflammation.

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Published In

Cell Host Microbe

DOI

EISSN

1934-6069

Publication Date

January 15, 2014

Volume

15

Issue

1

Start / End Page

95 / 102

Location

United States

Related Subject Headings

  • Sulfonamides
  • Pyrazoles
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Macrophages, Alveolar
  • Macrophage Activation
  • Lung
  • Inflammation
  • Immunology
 

Citation

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Kim, Y.-G., Udayanga, K. G. S., Totsuka, N., Weinberg, J. B., Núñez, G., & Shibuya, A. (2014). Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE₂. Cell Host Microbe, 15(1), 95–102. https://doi.org/10.1016/j.chom.2013.12.010
Kim, Yun-Gi, Kankanam Gamage Sanath Udayanga, Naoya Totsuka, Jason B. Weinberg, Gabriel Núñez, and Akira Shibuya. “Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE₂.Cell Host Microbe 15, no. 1 (January 15, 2014): 95–102. https://doi.org/10.1016/j.chom.2013.12.010.
Kim Y-G, Udayanga KGS, Totsuka N, Weinberg JB, Núñez G, Shibuya A. Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE₂. Cell Host Microbe. 2014 Jan 15;15(1):95–102.
Kim, Yun-Gi, et al. “Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE₂.Cell Host Microbe, vol. 15, no. 1, Jan. 2014, pp. 95–102. Pubmed, doi:10.1016/j.chom.2013.12.010.
Kim Y-G, Udayanga KGS, Totsuka N, Weinberg JB, Núñez G, Shibuya A. Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE₂. Cell Host Microbe. 2014 Jan 15;15(1):95–102.
Journal cover image

Published In

Cell Host Microbe

DOI

EISSN

1934-6069

Publication Date

January 15, 2014

Volume

15

Issue

1

Start / End Page

95 / 102

Location

United States

Related Subject Headings

  • Sulfonamides
  • Pyrazoles
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Macrophages, Alveolar
  • Macrophage Activation
  • Lung
  • Inflammation
  • Immunology