Sarcopenic obesity and the pathogenesis of exercise intolerance in heart failure with preserved ejection fraction.

Journal Article (Journal Article;Review)

Heart failure with preserved ejection fraction (HFpEF) is the most common form of heart failure (HF) in older adults. The primary chronic symptom in patients with HFpEF, even when well compensated, is severe exercise intolerance. Cardiac and peripheral functions contribute equally to exercise intolerance in HFpEF, though the latter has been the focus of fewer studies. Of note, multiple studies with exercise training have shown that exercise intolerance can improve significantly in the absence of improvements in exercise cardiac output, indicating a role of peripheral, noncardiac adaptations. In addition, clinical drug trials performed to date in HFpEF, all of which have focused on influencing cardiovascular function, have not been positive on primary clinical outcomes and most have not improved exercise capacity. Mounting evidence indicates that sarcopenic obesity, characterized by the coexistence of excess fat mass and decreased muscle mass, could contribute to the pathophysiology of exercise intolerance in older HFpEF patients and may provide avenues for novel treatments.

Full Text

Duke Authors

Cited Authors

  • Upadhya, B; Haykowsky, MJ; Eggebeen, J; Kitzman, DW

Published Date

  • June 2015

Published In

Volume / Issue

  • 12 / 3

Start / End Page

  • 205 - 214

PubMed ID

  • 25750186

Pubmed Central ID

  • PMC4790464

Electronic International Standard Serial Number (EISSN)

  • 1546-9549

Digital Object Identifier (DOI)

  • 10.1007/s11897-015-0257-5


  • eng

Conference Location

  • United States