The effect of Aliskiren on exercise capacity in older patients with heart failure and preserved ejection fraction: A randomized, placebo-controlled, double-blind trial.

Journal Article (Letter)

In older patients (70 ± 7 years) with chronic well-compensated heart failure with preserved ejection and controlled blood pressure, 6 months treatment with aliskiren (direct renin inhibitor) showed non-significant trends for modest improvements in peak exercise oxygen consumption (14.9 ± 0.2 mL kg-1 min-1 versus 14.4 ± 0.2 mL kg-1 min-1; P = .10, trend) and ventilatory anaerobic threshold (888 ± 19 mL/min versus 841 ± 18 mL/min; P = .08).

Full Text

Duke Authors

Cited Authors

  • Upadhya, B; Brubaker, PH; Morgan, TM; Eggebeen, JD; Jao, GT; Stewart, KP; Kitzman, DW

Published Date

  • July 2018

Published In

Volume / Issue

  • 201 /

Start / End Page

  • 164 - 167

PubMed ID

  • 29910050

Pubmed Central ID

  • PMC7707854

Electronic International Standard Serial Number (EISSN)

  • 1097-6744

Digital Object Identifier (DOI)

  • 10.1016/j.ahj.2018.03.019

Language

  • eng

Conference Location

  • United States