Skip to main content
Journal cover image

Left ventricular strain and strain rate by 2D speckle tracking in chronic thromboembolic pulmonary hypertension before and after pulmonary thromboendarterectomy.

Publication ,  Journal Article
Olson, N; Brown, JP; Kahn, AM; Auger, WR; Madani, MM; Waltman, TJ; Blanchard, DG
Published in: Cardiovasc Ultrasound
September 27, 2010

BACKGROUND: Echocardiographic evaluation of left ventricular (LV) strain and strain rate (SR) by 2D speckle tracking may be useful tools to assess chronic thromboembolic pulmonary hypertension (CTEPH) severity as well as response to successful pulmonary thromboendarterectomy (PTE). METHODS: We evaluated 30 patients with CTEPH before and after PTE using 2D speckle tracking measurements of LV radial and circumferential strain and SR in the short axis, and correlated the data with right heart catheterization (RHC). RESULTS: PTE resulted in a decrease in mean PA pressure (44 ± 15 to 29 ± 9 mmHg), decrease in PVR (950 ± 550 to 31 ± 160 [dyne-sec]/cm⁵), and an increase in cardiac output (3.9 ± 1.0 to 5.0 ± 1.0 L/min, p < 0.001 for all). Circumferential and posterior wall radial strain changed by -11% and +15% respectively (p < 0.001 for both). Circumferential SR and posterior wall radial SR changed by -7% and 6% after PTE. While the increase in posterior wall SR with PTE reached statistical significance (p = 0.04) circumferential SR did not (p = 0.07). In addition, septal radial strain and SR did not change significantly after PTE (p = 0.1 and 0.8 respectively). Linear regression analyses of circumferential and posterior wall radial strain and SR revealed little correlation between strain/SR measurements and PVR, mean PA pressure, or cardiac output. However, change in circumferential strain and change in posterior wall radial strain correlated moderately well with changes in PVR, mean PA pressure and cardiac output (r = 0.69, 0.76, and 0.51 for circumferential strain [p < 0.001 for all] and r = 0.7, 0.7, 0.45 for posterior wall radial strain [p = 0.001, 0.001, and 0.02, respectively]). CONCLUSIONS: LV circumferential and posterior wall radial strain change after relief of pulmonary arterial obstruction in patients with CTEPH, and these improvements occur rapidly. These changes in LV strain may reflect effects from improved LV diastolic filling, and may be useful non-invasive markers of successful PTE.

Duke Scholars

Published In

Cardiovasc Ultrasound

DOI

EISSN

1476-7120

Publication Date

September 27, 2010

Volume

8

Start / End Page

43

Location

England

Related Subject Headings

  • Ventricular Function, Left
  • Treatment Outcome
  • Retrospective Studies
  • Pulmonary Embolism
  • Pulmonary Artery
  • Middle Aged
  • Hypertension, Pulmonary
  • Humans
  • Heart Ventricles
  • Follow-Up Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Olson, N., Brown, J. P., Kahn, A. M., Auger, W. R., Madani, M. M., Waltman, T. J., & Blanchard, D. G. (2010). Left ventricular strain and strain rate by 2D speckle tracking in chronic thromboembolic pulmonary hypertension before and after pulmonary thromboendarterectomy. Cardiovasc Ultrasound, 8, 43. https://doi.org/10.1186/1476-7120-8-43
Olson, Nicholas, Jason P. Brown, Andrew M. Kahn, William R. Auger, Michael M. Madani, Thomas J. Waltman, and Daniel G. Blanchard. “Left ventricular strain and strain rate by 2D speckle tracking in chronic thromboembolic pulmonary hypertension before and after pulmonary thromboendarterectomy.Cardiovasc Ultrasound 8 (September 27, 2010): 43. https://doi.org/10.1186/1476-7120-8-43.
Olson N, Brown JP, Kahn AM, Auger WR, Madani MM, Waltman TJ, et al. Left ventricular strain and strain rate by 2D speckle tracking in chronic thromboembolic pulmonary hypertension before and after pulmonary thromboendarterectomy. Cardiovasc Ultrasound. 2010 Sep 27;8:43.
Olson, Nicholas, et al. “Left ventricular strain and strain rate by 2D speckle tracking in chronic thromboembolic pulmonary hypertension before and after pulmonary thromboendarterectomy.Cardiovasc Ultrasound, vol. 8, Sept. 2010, p. 43. Pubmed, doi:10.1186/1476-7120-8-43.
Olson N, Brown JP, Kahn AM, Auger WR, Madani MM, Waltman TJ, Blanchard DG. Left ventricular strain and strain rate by 2D speckle tracking in chronic thromboembolic pulmonary hypertension before and after pulmonary thromboendarterectomy. Cardiovasc Ultrasound. 2010 Sep 27;8:43.
Journal cover image

Published In

Cardiovasc Ultrasound

DOI

EISSN

1476-7120

Publication Date

September 27, 2010

Volume

8

Start / End Page

43

Location

England

Related Subject Headings

  • Ventricular Function, Left
  • Treatment Outcome
  • Retrospective Studies
  • Pulmonary Embolism
  • Pulmonary Artery
  • Middle Aged
  • Hypertension, Pulmonary
  • Humans
  • Heart Ventricles
  • Follow-Up Studies