Identifying resting-state effective connectivity abnormalities in drug-naïve major depressive disorder diagnosis via graph convolutional networks.

Journal Article (Journal Article)

Major depressive disorder (MDD) is a leading cause of disability; its symptoms interfere with social, occupational, interpersonal, and academic functioning. However, the diagnosis of MDD is still made by phenomenological approach. The advent of neuroimaging techniques allowed numerous studies to use resting-state functional magnetic resonance imaging (rs-fMRI) and estimate functional connectivity for brain-disease identification. Recently, attempts have been made to investigate effective connectivity (EC) that represents causal relations among regions of interest. In the meantime, to identify meaningful phenotypes for clinical diagnosis, graph-based approaches such as graph convolutional networks (GCNs) have been leveraged recently to explore complex pairwise similarities in imaging/nonimaging features among subjects. In this study, we validate the use of EC for MDD identification by estimating its measures via a group sparse representation along with a structured equation modeling approach in a whole-brain data-driven manner from rs-fMRI. To distinguish drug-naïve MDD patients from healthy controls, we utilize spectral GCNs based on a population graph to successfully integrate EC and nonimaging phenotypic information. Furthermore, we devise a novel sensitivity analysis method to investigate the discriminant connections for MDD identification in our trained GCNs. Our experimental results validated the effectiveness of our method in various scenarios, and we identified altered connectivities associated with the diagnosis of MDD.

Full Text

Duke Authors

Cited Authors

  • Jun, E; Na, K-S; Kang, W; Lee, J; Suk, H-I; Ham, B-J

Published Date

  • December 2020

Published In

Volume / Issue

  • 41 / 17

Start / End Page

  • 4997 - 5014

PubMed ID

  • 32813309

Pubmed Central ID

  • PMC7643383

Electronic International Standard Serial Number (EISSN)

  • 1097-0193

Digital Object Identifier (DOI)

  • 10.1002/hbm.25175


  • eng

Conference Location

  • United States