New insights into the function of IAP proteins: modulation of the MYC/MAX/MAD network.

Journal Article (Journal Article)

A growing number of studies have revealed that the inhibitor of apoptosis (IAP) proteins play a variety of cellular roles in addition to suppression of apoptosis. A recent study in Molecular Cell demonstrates that one IAP member, c-IAP1, functions to potentiate the activity of Myc by triggering the ubiquitination and proteasomal degradation of the Myc inhibitory protein Mad1.

Full Text

Duke Authors

Cited Authors

  • Wright, CW; Duckett, CS

Published Date

  • January 2008

Published In

Volume / Issue

  • 14 / 1

Start / End Page

  • 3 - 4

PubMed ID

  • 18194645

Pubmed Central ID

  • PMC2669287

International Standard Serial Number (ISSN)

  • 1534-5807

Digital Object Identifier (DOI)

  • 10.1016/j.devcel.2007.12.015


  • eng

Conference Location

  • United States