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The aryl hydrocarbon nuclear translocator alters CD30-mediated NF-kappaB-dependent transcription.

Publication ,  Journal Article
Wright, CW; Duckett, CS
Published in: Science
January 9, 2009

Expression and signaling of CD30, a tumor necrosis factor receptor family member, is up-regulated in numerous lymphoid-derived neoplasias, most notably anaplastic large-cell lymphoma (ALCL) and Hodgkin's lymphoma. To gain insight into the mechanism of CD30 signaling, we used an affinity purification strategy that led to the identification of the aryl hydrocarbon receptor nuclear translocator (ARNT) as a CD30-interacting protein that modulated the activity of the RelB subunit of the transcription factor nuclear factor kappaB (NF-kappaB). ALCL cells that were deficient in ARNT exhibited defects in RelB recruitment to NF-kappaB-responsive promoters, whereas RelA recruitment to the same sites was potentiated, resulting in the augmented expression of these NF-kappaB-responsive genes. These findings indicate that ARNT functions in concert with RelB in a CD30-induced negative feedback mechanism.

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Published In

Science

DOI

EISSN

1095-9203

Publication Date

January 9, 2009

Volume

323

Issue

5911

Start / End Page

251 / 255

Location

United States

Related Subject Headings

  • Transcriptional Activation
  • Transcription, Genetic
  • Transcription Factor RelB
  • Signal Transduction
  • Recombinant Fusion Proteins
  • Receptors, Tumor Necrosis Factor, Type II
  • Protein Structure, Tertiary
  • Promoter Regions, Genetic
  • NF-kappa B
  • Molecular Sequence Data
 

Citation

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Wright, C. W., & Duckett, C. S. (2009). The aryl hydrocarbon nuclear translocator alters CD30-mediated NF-kappaB-dependent transcription. Science, 323(5911), 251–255. https://doi.org/10.1126/science.1162818
Wright, Casey W., and Colin S. Duckett. “The aryl hydrocarbon nuclear translocator alters CD30-mediated NF-kappaB-dependent transcription.Science 323, no. 5911 (January 9, 2009): 251–55. https://doi.org/10.1126/science.1162818.
Wright, Casey W., and Colin S. Duckett. “The aryl hydrocarbon nuclear translocator alters CD30-mediated NF-kappaB-dependent transcription.Science, vol. 323, no. 5911, Jan. 2009, pp. 251–55. Pubmed, doi:10.1126/science.1162818.
Journal cover image

Published In

Science

DOI

EISSN

1095-9203

Publication Date

January 9, 2009

Volume

323

Issue

5911

Start / End Page

251 / 255

Location

United States

Related Subject Headings

  • Transcriptional Activation
  • Transcription, Genetic
  • Transcription Factor RelB
  • Signal Transduction
  • Recombinant Fusion Proteins
  • Receptors, Tumor Necrosis Factor, Type II
  • Protein Structure, Tertiary
  • Promoter Regions, Genetic
  • NF-kappa B
  • Molecular Sequence Data