Anti-HIV Macrocyclic Daphnane Orthoesters with an Unusual Macrocyclic Ring from Edgeworthia chrysantha.
Publication
, Journal Article
Asada, Y; Otsuki, K; Morooka, M; Huang, L; Chen, C-H; Koike, K; Li, W
Published in: J Nat Prod
October 28, 2022
Edgeworthianins A-E (1-5) were isolated from Edgeworthia chrysantha as a class of macrocyclic daphnane orthoesters with an unusual macrocyclic ring formed from a C14 aliphatic chain. Their structures were elucidated by extensive physicochemical and spectroscopic analyses. Compounds 2, 4, and 5 exhibited potent anti-HIV activity against HIV-1 infection of MT4 cells with EC50 values of 29.3, 8.4, and 2.9 nM, respectively. These compounds broaden the findings of the structure-activity relationship of macrocyclic daphnane orthoesters for further anti-HIV drug development.
Duke Scholars
Published In
J Nat Prod
DOI
EISSN
1520-6025
Publication Date
October 28, 2022
Volume
85
Issue
10
Start / End Page
2399 / 2405
Location
United States
Related Subject Headings
- Thymelaeaceae
- Structure-Activity Relationship
- Molecular Structure
- Medicinal & Biomolecular Chemistry
- Diterpenes
- Anti-HIV Agents
- 4208 Traditional, complementary and integrative medicine
- 11 Medical and Health Sciences
- 06 Biological Sciences
- 03 Chemical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Asada, Y., Otsuki, K., Morooka, M., Huang, L., Chen, C.-H., Koike, K., & Li, W. (2022). Anti-HIV Macrocyclic Daphnane Orthoesters with an Unusual Macrocyclic Ring from Edgeworthia chrysantha. J Nat Prod, 85(10), 2399–2405. https://doi.org/10.1021/acs.jnatprod.2c00618
Asada, Yoshihisa, Kouharu Otsuki, Miki Morooka, Li Huang, Chin-Ho Chen, Kazuo Koike, and Wei Li. “Anti-HIV Macrocyclic Daphnane Orthoesters with an Unusual Macrocyclic Ring from Edgeworthia chrysantha.” J Nat Prod 85, no. 10 (October 28, 2022): 2399–2405. https://doi.org/10.1021/acs.jnatprod.2c00618.
Asada Y, Otsuki K, Morooka M, Huang L, Chen C-H, Koike K, et al. Anti-HIV Macrocyclic Daphnane Orthoesters with an Unusual Macrocyclic Ring from Edgeworthia chrysantha. J Nat Prod. 2022 Oct 28;85(10):2399–405.
Asada, Yoshihisa, et al. “Anti-HIV Macrocyclic Daphnane Orthoesters with an Unusual Macrocyclic Ring from Edgeworthia chrysantha.” J Nat Prod, vol. 85, no. 10, Oct. 2022, pp. 2399–405. Pubmed, doi:10.1021/acs.jnatprod.2c00618.
Asada Y, Otsuki K, Morooka M, Huang L, Chen C-H, Koike K, Li W. Anti-HIV Macrocyclic Daphnane Orthoesters with an Unusual Macrocyclic Ring from Edgeworthia chrysantha. J Nat Prod. 2022 Oct 28;85(10):2399–2405.
Published In
J Nat Prod
DOI
EISSN
1520-6025
Publication Date
October 28, 2022
Volume
85
Issue
10
Start / End Page
2399 / 2405
Location
United States
Related Subject Headings
- Thymelaeaceae
- Structure-Activity Relationship
- Molecular Structure
- Medicinal & Biomolecular Chemistry
- Diterpenes
- Anti-HIV Agents
- 4208 Traditional, complementary and integrative medicine
- 11 Medical and Health Sciences
- 06 Biological Sciences
- 03 Chemical Sciences