Palliative care phenotypes among critically ill patients and family members: intensive care unit prospective cohort study.

OBJECTIVE: Because the heterogeneity of patients in intensive care units (ICUs) and family members represents a challenge to palliative care delivery, we aimed to determine if distinct phenotypes of palliative care needs exist. METHODS: Prospective cohort study conducted among family members of adult patients undergoing mechanical ventilation in six medical and surgical ICUs. The primary outcome was palliative care need measured by the Needs at the End-of-Life Screening Tool (NEST, range from 0 (no need) to 130 (highest need)) completed 3 days after ICU admission. We also assessed quality of communication, clinician-family relationship and patient centredness of care. Latent class analysis of the NEST's 13 items was used to identify groups with similar patterns of serious palliative care needs. RESULTS: Among 257 family members, latent class analysis yielded a four-class model including complex communication needs (n=26, 10%; median NEST score 68.0), family spiritual and cultural needs (n=21, 8%; 40.0) and patient and family stress needs (n=43, 31%; 31.0), as well as a fourth group with fewer serious needs (n=167, 65%; 14.0). Interclass differences existed in quality of communication (median range 4.0-10.0, p<0.001), favourable clinician-family relationship (range 34.6%-98.2%, p<0.001) and both the patient centredness of care Eliciting Concerns (median range 4.0-5.0, p<0.001) and Decision-Making (median range 2.3-4.5, p<0.001) scales. CONCLUSIONS: Four novel phenotypes of palliative care need were identified among ICU family members with distinct differences in the severity of needs and perceived quality of the clinician-family interaction. Knowledge of need class may help to inform the development of more person-centred models of ICU-based palliative care.

Duke Scholars

Author Mashael Al-Hegelan Medicine, Pulmonary, Allergy, and Critical Care Medicine

Author Robert William Harrison Medicine, Cardiology

Author Maren Karine Olsen Biostatistics & Bioinformatics, Division of Biostatistics

Author Christopher Ethan Cox Medicine, Pulmonary, Allergy, and Critical Care Medicine

Author Deepshikha Ashana Medicine, Pulmonary, Allergy, and Critical Care Medicine

Author Sharron Lee Docherty School of Nursing

Author Kimberly Sherell Johnson Medicine, Geriatrics

Author Jessica Ma Medicine, General Internal Medicine

Author Jessie Gu Medicine, Pulmonary, Allergy, and Critical Care Medicine

Author Alice Parish  

Author Elias Pratt Medicine, Pulmonary, Allergy, and Critical Care Medicine

Author Krista Lynn Haines Trauma, Acute, and Critical Care Surgery