Benchmarking definitions of false-positive alerts during computer-aided polyp detection in colonoscopy.

Journal Article (Journal Article)

BACKGROUND: The occurrence of false-positive alerts is an important outcome measure in computer-aided colon polyp detection (CADe) studies. However, there is no consensus definition of a false positive in clinical trials evaluating CADe in colonoscopy. We aimed to study the diagnostic performance of CADe based on different threshold definitions for false-positive alerts. METHODS: A previously validated CADe system was applied to screening/surveillance colonoscopy videos. Different thresholds for false-positive alerts were defined based on the time an alert box was continuously traced by the system. Primary outcomes were false-positive results and specificity using different threshold definitions of false positive. RESULTS: 62 colonoscopies were analyzed. CADe specificity and accuracy were 93.2 % and 97.8 %, respectively, for a threshold definition of ≥ 0.5 seconds, 98.6 % and 99.5 % for a threshold definition of ≥ 1 second, and 99.8 % and 99.9 % for a threshold definition of ≥ 2 seconds. CONCLUSION: Our analysis demonstrated how different threshold definitions of false positive can impact the reported diagnostic performance of CADe for colon polyp detection.

Full Text

Duke Authors

Cited Authors

  • Holzwanger, EA; Bilal, M; Glissen Brown, JR; Singh, S; Becq, A; Ernest-Suarez, K; Berzin, TM

Published Date

  • September 2021

Published In

Volume / Issue

  • 53 / 9

Start / End Page

  • 937 - 940

PubMed ID

  • 33137833

Pubmed Central ID

  • PMC8386281

Electronic International Standard Serial Number (EISSN)

  • 1438-8812

Digital Object Identifier (DOI)

  • 10.1055/a-1302-2942


  • eng

Conference Location

  • Germany