Increased Prevalence of Eosinophilic Esophagitis in Patients With Chronic Rhinosinusitis.

Journal Article (Journal Article)

BACKGROUND: Chronic rhinosinusitis (CRS) and eosinophilic esophagitis (EoE) are immune-mediated inflammatory conditions that share common histopathologic features. Once considered two separate pathologies, preliminary data has suggested that a higher prevalence of EoE may exist in patients with CRS. OBJECTIVES: We aimed to expand the base of evidence across geographic regions and investigate the association between EoE and CRS, including CRS with nasal polyposis (CRSwNP). METHODS: Quantitative data detailing the prevalence of CRS, CRSwNP, and EoE were pooled from 6 large academic institutions spread across the United States using Epic electronic medical record system. One-way analysis of variance was then used to analyze the data. RESULTS: The mean prevalence of EoE in our general population sample of over 26 million individual records was 0.058% (range, 0.013%-0.103%). The mean prevalence of EoE in our sub-populations of individual with diagnoses of CRS and CRSwNP was 0.43% (F(1,12)  =  [8.194], P  =  .01) and 0.84% (F(1,12)  =  [23.61], P < .01) respectively. CONCLUSION: This study reveals an 8-fold greater prevalence of concurrent EoE in patients with CRS. Importantly, this is the first study to describe the association of EoE and the CRSwNP subtype, and we demonstrate a 14-fold greater prevalence of EoE in patients with CRSwNP.

Full Text

Duke Authors

Cited Authors

  • Simmons, JK; Leiman, DA; Patil, SU; McCoul, E; Chen, PG; Tang, DM; Kuan, EC; Chang, EE; Wu, AW

Published Date

  • November 2022

Published In

Volume / Issue

  • 36 / 6

Start / End Page

  • 804 - 807

PubMed ID

  • 36112756

Electronic International Standard Serial Number (EISSN)

  • 1945-8932

Digital Object Identifier (DOI)

  • 10.1177/19458924221116162


  • eng

Conference Location

  • United States