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CD169-dependent cell-associated HIV-1 transmission: a driver of virus dissemination.

Publication ,  Journal Article
Gummuluru, S; Pina Ramirez, N-G; Akiyama, H
Published in: The Journal of infectious diseases
December 2014

Sexual transmission of human immunodeficiency virus type 1 (HIV-1) occurs across mucosal surfaces of the genital and gastrointestinal tracts and accounts for the vast majority of newly acquired infections worldwide. In the absence of an effective vaccine, interventional strategies such as microbicides that target viral attachment and entry into mucosa-resident target cells are particularly attractive and might have the greatest impact on reducing the HIV-1 pandemic. Rational development of microbicides would be greatly aided with a better understanding of several key questions of mucosal HIV-1 transmission, including the molecular mechanism(s) of how HIV-1 traverses mucosal barriers, the type of cells that it initially infects to gain a foothold in the naive host, and how it is disseminated from local sites of infection to draining lymph nodes. In this review, we discuss the role of myeloid dendritic cells (DCs) in cell-associated HIV-1 transmission and in facilitating systemic HIV-1 dissemination. We will evaluate the role of CD169 as a DC-associated HIV-1 attachment factor, investigate the molecular mechanisms by which HIV-1 particles are transferred from DCs to CD4(+) T cells across virological synapses, and provide arguments for inclusion of molecules in microbicides that can effectively target HIV-1 attachment to DCs and DC-mediated virus transfer.

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Published In

The Journal of infectious diseases

DOI

EISSN

1537-6613

ISSN

0022-1899

Publication Date

December 2014

Volume

210 Suppl 3

Start / End Page

S641 / S647

Related Subject Headings

  • Sialic Acid Binding Ig-like Lectin 1
  • Mucous Membrane
  • Microbiology
  • Humans
  • HIV-1
  • HIV Infections
  • Dendritic Cells
  • CD4-Positive T-Lymphocytes
  • Animals
  • 42 Health sciences
 

Citation

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ICMJE
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Gummuluru, S., Pina Ramirez, N.-G., & Akiyama, H. (2014). CD169-dependent cell-associated HIV-1 transmission: a driver of virus dissemination. The Journal of Infectious Diseases, 210 Suppl 3, S641–S647. https://doi.org/10.1093/infdis/jiu442
Gummuluru, Suryaram, Nora-Guadalupe Pina Ramirez, and Hisashi Akiyama. “CD169-dependent cell-associated HIV-1 transmission: a driver of virus dissemination.The Journal of Infectious Diseases 210 Suppl 3 (December 2014): S641–47. https://doi.org/10.1093/infdis/jiu442.
Gummuluru S, Pina Ramirez N-G, Akiyama H. CD169-dependent cell-associated HIV-1 transmission: a driver of virus dissemination. The Journal of infectious diseases. 2014 Dec;210 Suppl 3:S641–7.
Gummuluru, Suryaram, et al. “CD169-dependent cell-associated HIV-1 transmission: a driver of virus dissemination.The Journal of Infectious Diseases, vol. 210 Suppl 3, Dec. 2014, pp. S641–47. Epmc, doi:10.1093/infdis/jiu442.
Gummuluru S, Pina Ramirez N-G, Akiyama H. CD169-dependent cell-associated HIV-1 transmission: a driver of virus dissemination. The Journal of infectious diseases. 2014 Dec;210 Suppl 3:S641–S647.
Journal cover image

Published In

The Journal of infectious diseases

DOI

EISSN

1537-6613

ISSN

0022-1899

Publication Date

December 2014

Volume

210 Suppl 3

Start / End Page

S641 / S647

Related Subject Headings

  • Sialic Acid Binding Ig-like Lectin 1
  • Mucous Membrane
  • Microbiology
  • Humans
  • HIV-1
  • HIV Infections
  • Dendritic Cells
  • CD4-Positive T-Lymphocytes
  • Animals
  • 42 Health sciences