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Adjuvant radiation therapy increases disease-free survival in stage IB Merkel cell carcinoma.

Publication ,  Journal Article
Sexton, KW; Poteet, SP; Hill, JB; Schmidt, A; Patel, A; Del Corral, GA; Axt, J; Kelley, MC; Thayer, WP; Shack, RB
Published in: Ann Plast Surg
November 2014

Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignancy. Adjuvant radiation increases survival in advanced stages, but efficacy in stage I disease is unknown. A retrospective review included all patients treated for stage I MCC during a 15-year period at Vanderbilt University Medical Center. Among 42 patients, 26 (62%) had a negative sentinel lymph node biopsy (stage IA) and 16 (38%) had clinically negative lymph nodes (stage IB) at the time of resection. Analysis using Cox regression revealed that higher stage and absence of adjuvant radiation are associated with increased disease recurrence (hazard ratio, 6.29; P=0.003 and hazard ratio, 4.69; P=0.013, respectively). Controlling for stage, radiation therapy significantly increased disease-free survival among patients with stage IB disease (P=0.0026) in a log-rank test comparing Kaplan-Meier curves. These findings support adjuvant radiation therapy in stage IB MCC patients with clinically negative lymph nodes who do not undergo sentinel lymph node biopsy.

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Published In

Ann Plast Surg

DOI

EISSN

1536-3708

Publication Date

November 2014

Volume

73

Issue

5

Start / End Page

531 / 534

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Torso
  • Surgery
  • Skin Neoplasms
  • Retrospective Studies
  • Radiotherapy, Adjuvant
  • Proportional Hazards Models
  • Neoplasm Staging
  • Neoplasm Recurrence, Local
  • Middle Aged
 

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Sexton, K. W., Poteet, S. P., Hill, J. B., Schmidt, A., Patel, A., Del Corral, G. A., … Shack, R. B. (2014). Adjuvant radiation therapy increases disease-free survival in stage IB Merkel cell carcinoma. Ann Plast Surg, 73(5), 531–534. https://doi.org/10.1097/SAP.0b013e31827f4c58
Sexton, Kevin W., Stephen P. Poteet, John Bradford Hill, Alexandra Schmidt, Ashit Patel, Gabriel A. Del Corral, Jason Axt, Mark C. Kelley, Wesley P. Thayer, and Robert Bruce Shack. “Adjuvant radiation therapy increases disease-free survival in stage IB Merkel cell carcinoma.Ann Plast Surg 73, no. 5 (November 2014): 531–34. https://doi.org/10.1097/SAP.0b013e31827f4c58.
Sexton KW, Poteet SP, Hill JB, Schmidt A, Patel A, Del Corral GA, et al. Adjuvant radiation therapy increases disease-free survival in stage IB Merkel cell carcinoma. Ann Plast Surg. 2014 Nov;73(5):531–4.
Sexton, Kevin W., et al. “Adjuvant radiation therapy increases disease-free survival in stage IB Merkel cell carcinoma.Ann Plast Surg, vol. 73, no. 5, Nov. 2014, pp. 531–34. Pubmed, doi:10.1097/SAP.0b013e31827f4c58.
Sexton KW, Poteet SP, Hill JB, Schmidt A, Patel A, Del Corral GA, Axt J, Kelley MC, Thayer WP, Shack RB. Adjuvant radiation therapy increases disease-free survival in stage IB Merkel cell carcinoma. Ann Plast Surg. 2014 Nov;73(5):531–534.

Published In

Ann Plast Surg

DOI

EISSN

1536-3708

Publication Date

November 2014

Volume

73

Issue

5

Start / End Page

531 / 534

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Torso
  • Surgery
  • Skin Neoplasms
  • Retrospective Studies
  • Radiotherapy, Adjuvant
  • Proportional Hazards Models
  • Neoplasm Staging
  • Neoplasm Recurrence, Local
  • Middle Aged