Skip to main content

IRONMAN: A Novel International Registry of Men With Advanced Prostate Cancer.

Publication ,  Journal Article
Mucci, LA; Vinson, J; Gold, T; Gerke, T; Filipenko, J; Green, RM; Anderson, SG; Badal, S; Bjartell, A; Chi, KN; Davis, ID; Enting, D; Fay, AP ...
Published in: JCO Glob Oncol
November 2022

PURPOSE: To describe a newly established international registry recruiting diverse patients with advanced prostate cancer across academic and community practices to address unmet needs in this population. PATIENTS AND METHODS: Initiated in 2017, IRONMAN (International Registry for Men with Advanced Prostate Cancer) is a prospective cohort of patients with advanced prostate cancer. The study will enroll 5,000 patients with metastatic hormone-sensitive prostate cancer (mHSPC) or castration-resistant prostate cancer (CRPC), recruited from Australia, the Bahamas, Barbados, Brazil, Canada, Ireland, Jamaica, Kenya, Nigeria, Norway, South Africa, Spain, Sweden, Switzerland, the United Kingdom, and the United States. The study is collecting datatypes to study variation in care and treatment of advanced prostate cancer across countries and across academic, community-based, and government practices with a focus on clinical outcomes, patient-reported outcomes, epidemiologic data, biologic subtypes, and clinician questionnaires. RESULTS: Through July 2022, 2,682 eligible patients were enrolled in 11 of 12 active countries. Sixty-six percent of patients have mHSPC, and 34% have CRPC. On the basis of self-report, 11% of patients are Black and 9% are Hispanic. Five Veterans Affairs Medical Centers are enrolling patients. Globally, 23% of patients report being veterans of military service. CONCLUSION: To our knowledge, this is the first international cohort of people newly diagnosed with advanced prostate cancer designed to describe variations in patient management, experiences, and outcomes. IRONMAN aims to identify optimal treatment sequences to improve survival, understand patient-reported outcomes, and explore novel biomarkers to understand treatment resistance mechanisms. Insights from IRONMAN will inform and guide future clinical management of people with mHSPC and CRPC. This cohort study will provide real-world evidence to facilitate a better understanding of the survivorship of people with advanced prostate cancer.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

JCO Glob Oncol

DOI

EISSN

2687-8941

Publication Date

November 2022

Volume

8

Start / End Page

e2200154

Location

United States

Related Subject Headings

  • Spain
  • Registries
  • Prostatic Neoplasms, Castration-Resistant
  • Prospective Studies
  • Male
  • Humans
  • Cohort Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mucci, L. A., Vinson, J., Gold, T., Gerke, T., Filipenko, J., Green, R. M., … IRONMAN Global Team, . (2022). IRONMAN: A Novel International Registry of Men With Advanced Prostate Cancer. JCO Glob Oncol, 8, e2200154. https://doi.org/10.1200/GO.22.00154
Mucci, Lorelei A., Jacob Vinson, Theresa Gold, Travis Gerke, Julie Filipenko, Rebecca M. Green, Simon G. Anderson, et al. “IRONMAN: A Novel International Registry of Men With Advanced Prostate Cancer.JCO Glob Oncol 8 (November 2022): e2200154. https://doi.org/10.1200/GO.22.00154.
Mucci LA, Vinson J, Gold T, Gerke T, Filipenko J, Green RM, et al. IRONMAN: A Novel International Registry of Men With Advanced Prostate Cancer. JCO Glob Oncol. 2022 Nov;8:e2200154.
Mucci, Lorelei A., et al. “IRONMAN: A Novel International Registry of Men With Advanced Prostate Cancer.JCO Glob Oncol, vol. 8, Nov. 2022, p. e2200154. Pubmed, doi:10.1200/GO.22.00154.
Mucci LA, Vinson J, Gold T, Gerke T, Filipenko J, Green RM, Anderson SG, Badal S, Bjartell A, Chi KN, Davis ID, Enting D, Fay AP, Lazarus J, Mateo J, McDermott R, Odedina FT, Olmos D, Omlin A, Popoola AA, Ragin C, Roberts R, Russnes KM, Waihenya C, Stopsack KH, Hyslop T, Villanti P, Kantoff PW, George DJ, IRONMAN Global Team. IRONMAN: A Novel International Registry of Men With Advanced Prostate Cancer. JCO Glob Oncol. 2022 Nov;8:e2200154.

Published In

JCO Glob Oncol

DOI

EISSN

2687-8941

Publication Date

November 2022

Volume

8

Start / End Page

e2200154

Location

United States

Related Subject Headings

  • Spain
  • Registries
  • Prostatic Neoplasms, Castration-Resistant
  • Prospective Studies
  • Male
  • Humans
  • Cohort Studies