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Hippocampal convergence during anticipatory midbrain activation promotes subsequent memory formation.

Publication ,  Journal Article
Poh, J-H; Vu, M-AT; Stanek, JK; Hsiung, A; Egner, T; Adcock, RA
Published in: Nat Commun
November 7, 2022

The hippocampus has been a focus of memory research since H.M's surgery abolished his ability to form new memories, yet its mechanistic role in memory remains debated. Here, we identify a candidate memory mechanism: an anticipatory hippocampal "convergence state", observed while awaiting valuable information, and which predicts subsequent learning. During fMRI, participants viewed trivia questions eliciting high or low curiosity, followed seconds later by its answer. We reasoned that encoding success requires a confluence of conditions, so that hippocampal states more conducive to memory formation should converge in state space. To operationalize convergence of neural states, we quantified the typicality of multivoxel patterns in the medial temporal lobes during anticipation and encoding of trivia answers. We found that the typicality of anticipatory hippocampal patterns increased during high curiosity. Crucially, anticipatory hippocampal pattern typicality increased with dopaminergic midbrain activation and uniquely accounted for the association between midbrain activation and subsequent recall. We propose that hippocampal convergence states may complete a cascade from motivation and midbrain activation to memory enhancement, and may be a general predictor of memory formation.

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Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

November 7, 2022

Volume

13

Issue

1

Start / End Page

6729

Location

England

Related Subject Headings

  • Temporal Lobe
  • Mesencephalon
  • Mental Recall
  • Magnetic Resonance Imaging
  • Learning
  • Humans
  • Hippocampus
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Poh, J.-H., Vu, M.-A., Stanek, J. K., Hsiung, A., Egner, T., & Adcock, R. A. (2022). Hippocampal convergence during anticipatory midbrain activation promotes subsequent memory formation. Nat Commun, 13(1), 6729. https://doi.org/10.1038/s41467-022-34459-3
Poh, Jia-Hou, Mai-Anh T. Vu, Jessica K. Stanek, Abigail Hsiung, Tobias Egner, and R Alison Adcock. “Hippocampal convergence during anticipatory midbrain activation promotes subsequent memory formation.Nat Commun 13, no. 1 (November 7, 2022): 6729. https://doi.org/10.1038/s41467-022-34459-3.
Poh J-H, Vu M-AT, Stanek JK, Hsiung A, Egner T, Adcock RA. Hippocampal convergence during anticipatory midbrain activation promotes subsequent memory formation. Nat Commun. 2022 Nov 7;13(1):6729.
Poh, Jia-Hou, et al. “Hippocampal convergence during anticipatory midbrain activation promotes subsequent memory formation.Nat Commun, vol. 13, no. 1, Nov. 2022, p. 6729. Pubmed, doi:10.1038/s41467-022-34459-3.
Poh J-H, Vu M-AT, Stanek JK, Hsiung A, Egner T, Adcock RA. Hippocampal convergence during anticipatory midbrain activation promotes subsequent memory formation. Nat Commun. 2022 Nov 7;13(1):6729.

Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

November 7, 2022

Volume

13

Issue

1

Start / End Page

6729

Location

England

Related Subject Headings

  • Temporal Lobe
  • Mesencephalon
  • Mental Recall
  • Magnetic Resonance Imaging
  • Learning
  • Humans
  • Hippocampus