Transvenous Endomyocardial Biopsy Technique for Intra-abdominal Heterotopic Cardiac Grafts.

Journal Article (Journal Article)

The porcine intra-abdominal heterotopic heart transplantation model allows for the assessment of immunologic effects on cardiac transplantation without relying on the allograft to maintain hemodynamic support for the animal. Historically, allograft function and histology is monitored by physical exam, echocardiogram evaluation, percutaneous core biopsy, and open biopsy. We performed transvenous endomyocardial biopsies in three pigs that had undergone heterotopic heart implantation. We describe the procedure to be feasible and reproducible, and that histologic results from these biopsies correlated with those from corresponding tissue collected by surgical dissection at the time of allograft explantation. The ability to perform endomyocardial biopsies in the heterotopic heart transplantation model allows for serial non-invasive monitoring of allograft histology.

Full Text

Duke Authors

Cited Authors

  • Mendiola Pla, M; Milano, CA; Chiang, Y; Bishawi, M; Kang, L; Lee, FH; Smith, MF; Gross, RT; Contreras, FJ; Glass, C; Bowles, DE; Fudim, M

Published Date

  • November 7, 2022

Published In

PubMed ID

  • 36344902

Electronic International Standard Serial Number (EISSN)

  • 1937-5395

Digital Object Identifier (DOI)

  • 10.1007/s12265-022-10337-7


  • eng

Conference Location

  • United States