The Use of Adenosine in Cerebral Aneurysm Clipping: A Review

Journal Article (Journal Article)

Management of intracranial aneurysms continues to evolve, with coiling of aneurysms becoming an increasingly used modality. However, for aneurysms which are considered to be “complex” due to their size, position, or morphology, clipping continues to be the preferred treatment option. Several techniques can be utilized intraoperatively to facilitate aneurysm exposure and clip ligation. These include deep hypothermic circulatory arrest, endovascular balloon occlusion with suction, and, most commonly, temporary clip application to the proximal feeding vessel. The use of these techniques has been limited by the associated significant morbidity and mortality, and in the case of temporary clipping, anatomic limitations preventing clip application in certain cases. Recently, adenosine induced transient circulatory arrest has undergone a resurgence in neurosurgical practice to assist in complex aneurysm clip ligation. In this article we review this technique with special emphasis on appropriate patient selection and safety profile.

Full Text

Duke Authors

Cited Authors

  • Khan, SA; Nimjee, SM; Guinn, NN; Zomorodi, AR; Lam, AM; Britz, GW; McDonagh, DL

Published Date

  • September 1, 2013

Published In

Volume / Issue

  • 3 / 3

Start / End Page

  • 210 - 213

Electronic International Standard Serial Number (EISSN)

  • 1523-3855

International Standard Serial Number (ISSN)

  • 2167-6275

Digital Object Identifier (DOI)

  • 10.1007/s40140-013-0018-5

Citation Source

  • Scopus