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Self-reported subjective cognitive decline is associated with global cognition in a community sample of Latinos/as/x living in the United States.

Publication ,  Journal Article
Nakhla, MZ; Cohen, L; Salmon, DP; Smirnov, DS; Marquine, MJ; Moore, AA; Schiehser, DM; Zlatar, ZZ
Published in: J Clin Exp Neuropsychol
September 2021

INTRODUCTION: Although subjective cognitive decline (SCD) may be an early risk marker of Alzheimer's Disease (AD), research on SCD among Hispanics/Latinos/as/x (henceforth Latinos/as) living in the U.S. is lacking. We investigated if the cross-sectional relationship of self-reported SCD with objective cognition varies as a function of ethnic background (Latinos/as versus Non-Hispanic Whites [NHWs]). Secondary analyses conducted solely within the Latino/a group investigated if informant reported SCD is associated with objective cognition and whether self-reported SCD is related to markers of brain health in a sub-sample of Latinos/as with available MRI data. METHODS: Eighty-three participants (≥60 years of age) without dementia (35 Latinos/as; 48 NHWs) completed the Mattis Dementia Rating Scale (MDRS) and the Subjective Cognitive Decline-Questionnaire (SCD-Q). Additionally, 22 Latino/a informants completed the informant-version of the SCD-Q. Hierarchical regression models investigated if ethnicity moderates the association of MDRS and SCD-Q scores after adjusting for demographics and depressive symptoms. Correlational analyses within the Latino/a group investigated self- and informant-reported associations of SCD-Q scores with objective cognition, and associations of self-reported SCD-Q scores with medial temporal lobe volume and thickness. RESULTS: Latinos/as had lower education and MDRS scores than NHWs. Higher SCD-Q scores were associated with lower MDRS scores only in Latinos/as. Within the Latino/a group, self, but not informant reported SCD was related to objective cognition. Medium to large effect sizes were found whereby higher self-reported SCD was associated with lower entorhinal cortex thickness and left hippocampal volume in Latinos/as. CONCLUSIONS: The association of SCD and concurrent objectively measured global cognition varied by ethnic background and was only significant in Latinos/as. Self-reported SCD may be an indicator of cognitive and brain health in Latinos/as without dementia, prompting clinicians to monitor cognition. Future studies should explore if SCD predicts objective cognitive decline in diverse groups of Latinos/as living in the U.S.

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Published In

J Clin Exp Neuropsychol

DOI

EISSN

1744-411X

Publication Date

September 2021

Volume

43

Issue

7

Start / End Page

663 / 676

Location

England

Related Subject Headings

  • United States
  • Self Report
  • Neuropsychological Tests
  • Humans
  • Hispanic or Latino
  • Experimental Psychology
  • Cognitive Dysfunction
  • Cognition
  • 5204 Cognitive and computational psychology
  • 5203 Clinical and health psychology
 

Citation

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Nakhla, M. Z., Cohen, L., Salmon, D. P., Smirnov, D. S., Marquine, M. J., Moore, A. A., … Zlatar, Z. Z. (2021). Self-reported subjective cognitive decline is associated with global cognition in a community sample of Latinos/as/x living in the United States. J Clin Exp Neuropsychol, 43(7), 663–676. https://doi.org/10.1080/13803395.2021.1989381
Nakhla, Marina Z., Lynn Cohen, David P. Salmon, Denis S. Smirnov, María J. Marquine, Alison A. Moore, Dawn M. Schiehser, and Zvinka Z. Zlatar. “Self-reported subjective cognitive decline is associated with global cognition in a community sample of Latinos/as/x living in the United States.J Clin Exp Neuropsychol 43, no. 7 (September 2021): 663–76. https://doi.org/10.1080/13803395.2021.1989381.
Nakhla MZ, Cohen L, Salmon DP, Smirnov DS, Marquine MJ, Moore AA, et al. Self-reported subjective cognitive decline is associated with global cognition in a community sample of Latinos/as/x living in the United States. J Clin Exp Neuropsychol. 2021 Sep;43(7):663–76.
Nakhla, Marina Z., et al. “Self-reported subjective cognitive decline is associated with global cognition in a community sample of Latinos/as/x living in the United States.J Clin Exp Neuropsychol, vol. 43, no. 7, Sept. 2021, pp. 663–76. Pubmed, doi:10.1080/13803395.2021.1989381.
Nakhla MZ, Cohen L, Salmon DP, Smirnov DS, Marquine MJ, Moore AA, Schiehser DM, Zlatar ZZ. Self-reported subjective cognitive decline is associated with global cognition in a community sample of Latinos/as/x living in the United States. J Clin Exp Neuropsychol. 2021 Sep;43(7):663–676.

Published In

J Clin Exp Neuropsychol

DOI

EISSN

1744-411X

Publication Date

September 2021

Volume

43

Issue

7

Start / End Page

663 / 676

Location

England

Related Subject Headings

  • United States
  • Self Report
  • Neuropsychological Tests
  • Humans
  • Hispanic or Latino
  • Experimental Psychology
  • Cognitive Dysfunction
  • Cognition
  • 5204 Cognitive and computational psychology
  • 5203 Clinical and health psychology