Subjective cognitive decline and objective cognition among diverse U.S. Hispanics/Latinos: Results from the Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA).

Journal Article (Journal Article)

INTRODUCTION: Despite increased risk of cognitive decline in Hispanics/Latinos, research on early risk markers of Alzheimer's disease in this group is lacking. Subjective cognitive decline (SCD) may be an early risk marker of pathological aging. We investigated associations of SCD with objective cognition among a diverse sample of Hispanics/Latinos living in the United States. METHODS: SCD was measured with the Everyday Cognition Short Form (ECog-12) and cognitive performance with a standardized battery in 6125 adults aged ≥ 50 years without mild cognitive impairment or dementia (x̄age  = 63.2 years, 54.5% women). Regression models interrogated associations of SCD with objective global, memory, and executive function scores. RESULTS: Higher SCD was associated with lower objective global (B = -0.16, SE = 0.01), memory (B = -0.13, SE = 0.02), and executive (B = -0.13, SE = 0.02, p's < .001) function composite scores in fully adjusted models. DISCUSSION: Self-reported SCD, using the ECog-12, may be an indicator of concurrent objective cognition in diverse middle-aged and older community-dwelling Hispanics/Latinos.

Full Text

Duke Authors

Cited Authors

  • Zlatar, ZZ; Tarraf, W; González, KA; Vásquez, PM; Marquine, MJ; Lipton, RB; Gallo, LC; Khambaty, T; Zeng, D; Youngblood, ME; Estrella, ML; Isasi, CR; Daviglus, M; González, HM

Published Date

  • January 2022

Published In

Volume / Issue

  • 18 / 1

Start / End Page

  • 43 - 52

PubMed ID

  • 34057776

Pubmed Central ID

  • PMC8630099

Electronic International Standard Serial Number (EISSN)

  • 1552-5279

Digital Object Identifier (DOI)

  • 10.1002/alz.12381


  • eng

Conference Location

  • United States