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Redefining Aging in HIV Infection Using Phenotypes.

Publication ,  Journal Article
Stoff, DM; Goodkin, K; Jeste, D; Marquine, M
Published in: Curr HIV/AIDS Rep
October 2017

PURPOSE OF REVIEW: This article critically reviews the utility of "phenotypes" as behavioral descriptors in aging/HIV research that inform biological underpinnings and treatment development. We adopt a phenotypic redefinition of aging conceptualized within a broader context of HIV infection and of aging. Phenotypes are defined as dimensions of behavior, closely related to fundamental mechanisms, and, thus, may be more informative than chronological age. Primary emphasis in this review is given to comorbid aging and cognitive aging, though other phenotypes (i.e., disability, frailty, accelerated aging, successful aging) are also discussed in relation to comorbid aging and cognitive aging. RECENT FINDINGS: The main findings that emerged from this review are as follows: (1) the phenotypes, comorbid aging and cognitive aging, are distinct from each other, yet overlapping; (2) associative relationships are the rule in HIV for comorbid and cognitive aging phenotypes; and (3) HIV behavioral interventions for both comorbid aging and cognitive aging have been limited. Three paths for research progress are identified for phenotype-defined aging/HIV research (i.e., clinical and behavioral specification, biological mechanisms, intervention targets), and some important research questions are suggested within each of these research paths.

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Published In

Curr HIV/AIDS Rep

DOI

EISSN

1548-3576

Publication Date

October 2017

Volume

14

Issue

5

Start / End Page

184 / 199

Location

United States

Related Subject Headings

  • Virology
  • Phenotype
  • Humans
  • HIV Infections
  • Comorbidity
  • Cognitive Dysfunction
  • Aging
  • 3204 Immunology
  • 3202 Clinical sciences
  • 1108 Medical Microbiology
 

Citation

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ICMJE
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Stoff, D. M., Goodkin, K., Jeste, D., & Marquine, M. (2017). Redefining Aging in HIV Infection Using Phenotypes. Curr HIV/AIDS Rep, 14(5), 184–199. https://doi.org/10.1007/s11904-017-0364-x
Stoff, David M., Karl Goodkin, Dilip Jeste, and Maria Marquine. “Redefining Aging in HIV Infection Using Phenotypes.Curr HIV/AIDS Rep 14, no. 5 (October 2017): 184–99. https://doi.org/10.1007/s11904-017-0364-x.
Stoff DM, Goodkin K, Jeste D, Marquine M. Redefining Aging in HIV Infection Using Phenotypes. Curr HIV/AIDS Rep. 2017 Oct;14(5):184–99.
Stoff, David M., et al. “Redefining Aging in HIV Infection Using Phenotypes.Curr HIV/AIDS Rep, vol. 14, no. 5, Oct. 2017, pp. 184–99. Pubmed, doi:10.1007/s11904-017-0364-x.
Stoff DM, Goodkin K, Jeste D, Marquine M. Redefining Aging in HIV Infection Using Phenotypes. Curr HIV/AIDS Rep. 2017 Oct;14(5):184–199.
Journal cover image

Published In

Curr HIV/AIDS Rep

DOI

EISSN

1548-3576

Publication Date

October 2017

Volume

14

Issue

5

Start / End Page

184 / 199

Location

United States

Related Subject Headings

  • Virology
  • Phenotype
  • Humans
  • HIV Infections
  • Comorbidity
  • Cognitive Dysfunction
  • Aging
  • 3204 Immunology
  • 3202 Clinical sciences
  • 1108 Medical Microbiology