Skip to main content
Journal cover image

Major depression and the biological hallmarks of aging.

Publication ,  Journal Article
Lorenzo, EC; Kuchel, GA; Kuo, C-L; Moffitt, TE; Diniz, BS
Published in: Ageing research reviews
January 2023

Major depressive disorder (MDD) is characterized by psychological and physiological manifestations contributing to the disease severity and outcome. In recent years, several lines of evidence have suggested that individuals with MDD have an elevated risk of age-related adverse outcomes across the lifespan. This review provided evidence of a significant overlap between the biological abnormalities in MDD and biological changes commonly observed during the aging process (i.e., hallmarks of biological aging). Based on such evidence, we formulate a mechanistic model showing how abnormalities in the hallmarks of biological aging can be a common denominator and mediate the elevated risk of age-related health outcomes commonly observed in MDD. Finally, we proposed a roadmap for novel studies to investigate the intersection between the biology of aging and MDD, including the use of geroscience-guided interventions, such as senolytics, to delay or improve major depression by targeting biological aging.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Ageing research reviews

DOI

EISSN

1872-9649

ISSN

1568-1637

Publication Date

January 2023

Volume

83

Start / End Page

101805

Related Subject Headings

  • Longevity
  • Humans
  • Gerontology
  • Depressive Disorder, Major
  • Depression
  • Aging
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 3101 Biochemistry and cell biology
  • 1109 Neurosciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lorenzo, E. C., Kuchel, G. A., Kuo, C.-L., Moffitt, T. E., & Diniz, B. S. (2023). Major depression and the biological hallmarks of aging. Ageing Research Reviews, 83, 101805. https://doi.org/10.1016/j.arr.2022.101805
Lorenzo, Erica C., George A. Kuchel, Chia-Ling Kuo, Terrie E. Moffitt, and Breno S. Diniz. “Major depression and the biological hallmarks of aging.Ageing Research Reviews 83 (January 2023): 101805. https://doi.org/10.1016/j.arr.2022.101805.
Lorenzo EC, Kuchel GA, Kuo C-L, Moffitt TE, Diniz BS. Major depression and the biological hallmarks of aging. Ageing research reviews. 2023 Jan;83:101805.
Lorenzo, Erica C., et al. “Major depression and the biological hallmarks of aging.Ageing Research Reviews, vol. 83, Jan. 2023, p. 101805. Epmc, doi:10.1016/j.arr.2022.101805.
Lorenzo EC, Kuchel GA, Kuo C-L, Moffitt TE, Diniz BS. Major depression and the biological hallmarks of aging. Ageing research reviews. 2023 Jan;83:101805.
Journal cover image

Published In

Ageing research reviews

DOI

EISSN

1872-9649

ISSN

1568-1637

Publication Date

January 2023

Volume

83

Start / End Page

101805

Related Subject Headings

  • Longevity
  • Humans
  • Gerontology
  • Depressive Disorder, Major
  • Depression
  • Aging
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 3101 Biochemistry and cell biology
  • 1109 Neurosciences