NCCN Guidelines® Insights: Gastrointestinal Stromal Tumors, Version 2.2022.

Journal Article (Journal Article)

Gastrointestinal stromal tumors (GIST) are the most common type of soft tissue sarcoma that occur throughout the gastrointestinal tract. Most of these tumors are caused by oncogenic activating mutations in the KIT or PDGFRA genes. The NCCN Guidelines for GIST provide recommendations for the diagnosis, evaluation, treatment, and follow-up of patients with these tumors. These NCCN Guidelines Insights summarize the panel discussion behind recent important updates to the guidelines, including revised systemic therapy options for unresectable, progressive, or metastatic GIST based on mutational status, and updated recommendations for the management of GIST that develop resistance to specific tyrosine kinase inhibitors.

Full Text

Duke Authors

Cited Authors

  • von Mehren, M; Kane, JM; Riedel, RF; Sicklick, JK; Pollack, SM; Agulnik, M; Bui, MM; Carr-Ascher, J; Choy, E; Connelly, M; Dry, S; Ganjoo, KN; Gonzalez, RJ; Holder, A; Homsi, J; Keedy, V; Kelly, CM; Kim, E; Liebner, D; McCarter, M; McGarry, SV; Mesko, NW; Meyer, C; Pappo, AS; Parkes, AM; Petersen, IA; Poppe, M; Schuetze, S; Shabason, J; Spraker, MB; Zimel, M; Bergman, MA; Sundar, H; Hang, LE

Published Date

  • November 2022

Published In

Volume / Issue

  • 20 / 11

Start / End Page

  • 1204 - 1214

PubMed ID

  • 36351335

Electronic International Standard Serial Number (EISSN)

  • 1540-1413

Digital Object Identifier (DOI)

  • 10.6004/jnccn.2022.0058


  • eng

Conference Location

  • United States