We argue that decoupling, defined as the process of weakening interdependence between two nations or blocs of nations, has been ongoing between China and the United States and is likely to accelerate, with major implications for IB and MNE strategies and management. We present data that the world has experienced deglobalization and China-US decoupling and discuss the dynamics underlying decoupling and their implications for IB. We propose an initial framework of variations in decoupling by industry characteristics, and we outline novel and important questions for IB research growing out of our analysis. We conclude with a brief exposition of possible alternative scenarios.