Skip to main content

Giant Pancreatic Myoepithelial Hamartoma in a Patient With Familial Insulin-Dependent Diabetes Mellitus.

Publication ,  Journal Article
Sharib, J; Ord, JR; Bentley, RC; Shi, C; Blazer, DG
Published in: Pancreas
August 1, 2022

Pancreatic myoepithelial hamartoma is a rare, benign solid and cystic lesion of the pancreas. We present the first case of an adult with a giant myoepithelial hamartoma extending throughout the pancreas in a patient with diabetes in 4 immediate family members. The patient is a 46-year-old man presented with recurrent acute pancreatitis. Computed tomographic imaging showed that the head and body of the pancreas were replaced by a solid-cystic mass with focal calcification. Medical history includes insulin-dependent diabetes mellitus (IDDM) diagnosed at age 30. Endoscopic ultrasound-guided fine-needle aspiration showed pancreatic acinar tissue and smooth muscle without evidence of malignancy. Total pancreatectomy was performed because of the diffuse nature of the cystic disease and preexisting IDDM. The histopathologic diagnosis was consistent with myoepithelial hamartoma. In addition, there was a family history of IDDM and hamartomatous cyst resection in the paternal grandmother. We report the first case of diffuse pancreatic myoepithelial hamartoma with near total replacement of the entire pancreatic parenchyma, and the first reported case associated with a family history of heritable IDDM. Improved knowledge of the genetics, development, and malignant potential of such rare diseases is critical to determine appropriate management for patients.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Pancreas

DOI

EISSN

1536-4828

Publication Date

August 1, 2022

Volume

51

Issue

7

Start / End Page

830 / 833

Location

United States

Related Subject Headings

  • Pancreatitis
  • Pancreatic Neoplasms
  • Pancreas
  • Middle Aged
  • Male
  • Humans
  • Hamartoma
  • Gastroenterology & Hepatology
  • Diabetes Mellitus, Type 1
  • Adult
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sharib, J., Ord, J. R., Bentley, R. C., Shi, C., & Blazer, D. G. (2022). Giant Pancreatic Myoepithelial Hamartoma in a Patient With Familial Insulin-Dependent Diabetes Mellitus. Pancreas, 51(7), 830–833. https://doi.org/10.1097/MPA.0000000000002110
Sharib, Jeremy, Jeffrey R. Ord, Rex C. Bentley, Chanjuan Shi, and Dan G. Blazer. “Giant Pancreatic Myoepithelial Hamartoma in a Patient With Familial Insulin-Dependent Diabetes Mellitus.Pancreas 51, no. 7 (August 1, 2022): 830–33. https://doi.org/10.1097/MPA.0000000000002110.
Sharib J, Ord JR, Bentley RC, Shi C, Blazer DG. Giant Pancreatic Myoepithelial Hamartoma in a Patient With Familial Insulin-Dependent Diabetes Mellitus. Pancreas. 2022 Aug 1;51(7):830–3.
Sharib, Jeremy, et al. “Giant Pancreatic Myoepithelial Hamartoma in a Patient With Familial Insulin-Dependent Diabetes Mellitus.Pancreas, vol. 51, no. 7, Aug. 2022, pp. 830–33. Pubmed, doi:10.1097/MPA.0000000000002110.
Sharib J, Ord JR, Bentley RC, Shi C, Blazer DG. Giant Pancreatic Myoepithelial Hamartoma in a Patient With Familial Insulin-Dependent Diabetes Mellitus. Pancreas. 2022 Aug 1;51(7):830–833.

Published In

Pancreas

DOI

EISSN

1536-4828

Publication Date

August 1, 2022

Volume

51

Issue

7

Start / End Page

830 / 833

Location

United States

Related Subject Headings

  • Pancreatitis
  • Pancreatic Neoplasms
  • Pancreas
  • Middle Aged
  • Male
  • Humans
  • Hamartoma
  • Gastroenterology & Hepatology
  • Diabetes Mellitus, Type 1
  • Adult