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Eosinophilia in cancer and its regulation by sex hormones.

Publication ,  Journal Article
Artham, S; Chang, C-Y; McDonnell, DP
Published in: Trends Endocrinol Metab
January 2023

Gender differences in the functionality of the immune system have been attributed, in part, to direct and indirect effects of sex steroids, especially estrogens, on immune cell repertoire and activity. Notable are studies that have defined roles for estrogens in the regulation of the biology of dendritic cells (DCs), macrophages, T cells and natural killer (NK) cells. Although estrogens can modulate eosinophil function, the mechanisms by which this occurs and how it contributes to the pathobiology of different diseases remains underexplored. Furthermore, although the importance of eosinophils in infection is well established, it remains unclear as to how these innate immune cells, which are present in different tumors, impact the biology of cancer cells and/or response to therapeutics. The observation that eosinophilia influences the efficacy of immune checkpoint blockers (ICBs) is significant considering the role of estrogens as regulators of eosinophil function and recent studies suggesting that response to ICBs is impacted by gender. Thus, in this review, we consider what is known about the roles of estrogen(s) in regulating tissue eosinophilia/eosinophil function and how this influences the pathobiology of breast cancer (in particular). This information provides the context for a discussion of how estrogens/the estrogen receptor (ER) signaling axis can be targeted in eosinophils and how this would be expected to influence the activity of standard-of-care interventions and contemporary immunotherapy regimens in cancer(s).

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Published In

Trends Endocrinol Metab

DOI

EISSN

1879-3061

Publication Date

January 2023

Volume

34

Issue

1

Start / End Page

5 / 20

Location

United States

Related Subject Headings

  • Humans
  • Gonadal Steroid Hormones
  • Female
  • Estrogens
  • Eosinophils
  • Eosinophilia
  • Endocrinology & Metabolism
  • Breast Neoplasms
  • 3215 Reproductive medicine
  • 1114 Paediatrics and Reproductive Medicine
 

Citation

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Artham, S., Chang, C.-Y., & McDonnell, D. P. (2023). Eosinophilia in cancer and its regulation by sex hormones. Trends Endocrinol Metab, 34(1), 5–20. https://doi.org/10.1016/j.tem.2022.11.002
Artham, Sandeep, Ching-Yi Chang, and Donald P. McDonnell. “Eosinophilia in cancer and its regulation by sex hormones.Trends Endocrinol Metab 34, no. 1 (January 2023): 5–20. https://doi.org/10.1016/j.tem.2022.11.002.
Artham S, Chang C-Y, McDonnell DP. Eosinophilia in cancer and its regulation by sex hormones. Trends Endocrinol Metab. 2023 Jan;34(1):5–20.
Artham, Sandeep, et al. “Eosinophilia in cancer and its regulation by sex hormones.Trends Endocrinol Metab, vol. 34, no. 1, Jan. 2023, pp. 5–20. Pubmed, doi:10.1016/j.tem.2022.11.002.
Artham S, Chang C-Y, McDonnell DP. Eosinophilia in cancer and its regulation by sex hormones. Trends Endocrinol Metab. 2023 Jan;34(1):5–20.
Journal cover image

Published In

Trends Endocrinol Metab

DOI

EISSN

1879-3061

Publication Date

January 2023

Volume

34

Issue

1

Start / End Page

5 / 20

Location

United States

Related Subject Headings

  • Humans
  • Gonadal Steroid Hormones
  • Female
  • Estrogens
  • Eosinophils
  • Eosinophilia
  • Endocrinology & Metabolism
  • Breast Neoplasms
  • 3215 Reproductive medicine
  • 1114 Paediatrics and Reproductive Medicine