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Toward predictive engineering of gene circuits.

Publication ,  Journal Article
Şimşek, E; Yao, Y; Lee, D; You, L
Published in: Trends in biotechnology
June 2023

Many synthetic biology applications rely on programming living cells using gene circuits - the assembly and wiring of genetic elements to control cellular behaviors. Extensive progress has been made in constructing gene circuits with diverse functions and applications. For many circuit functions, however, it remains challenging to ensure that the circuits operate in a predictable manner. Although the notion of predictability may appear intuitive, close inspection suggests that it is not always clear what constitutes predictability. We dissect this concept and how it can be confounded by the complexity of a circuit, the complexity of the context, and the interplay between the two. We discuss circuit engineering strategies, in both computation and experiment, that have been used to improve the predictability of gene circuits.

Duke Scholars

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Published In

Trends in biotechnology

DOI

EISSN

1879-3096

ISSN

0167-7799

Publication Date

June 2023

Volume

41

Issue

6

Start / End Page

760 / 768

Related Subject Headings

  • Synthetic Biology
  • Genetic Engineering
  • Gene Regulatory Networks
  • Biotechnology
  • 3206 Medical biotechnology
  • 3106 Industrial biotechnology
  • 3001 Agricultural biotechnology
  • 10 Technology
  • 09 Engineering
  • 06 Biological Sciences
 

Citation

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ICMJE
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Şimşek, E., Yao, Y., Lee, D., & You, L. (2023). Toward predictive engineering of gene circuits. Trends in Biotechnology, 41(6), 760–768. https://doi.org/10.1016/j.tibtech.2022.11.001
Şimşek, Emrah, Yi Yao, Dongheon Lee, and Lingchong You. “Toward predictive engineering of gene circuits.Trends in Biotechnology 41, no. 6 (June 2023): 760–68. https://doi.org/10.1016/j.tibtech.2022.11.001.
Şimşek E, Yao Y, Lee D, You L. Toward predictive engineering of gene circuits. Trends in biotechnology. 2023 Jun;41(6):760–8.
Şimşek, Emrah, et al. “Toward predictive engineering of gene circuits.Trends in Biotechnology, vol. 41, no. 6, June 2023, pp. 760–68. Epmc, doi:10.1016/j.tibtech.2022.11.001.
Şimşek E, Yao Y, Lee D, You L. Toward predictive engineering of gene circuits. Trends in biotechnology. 2023 Jun;41(6):760–768.
Journal cover image

Published In

Trends in biotechnology

DOI

EISSN

1879-3096

ISSN

0167-7799

Publication Date

June 2023

Volume

41

Issue

6

Start / End Page

760 / 768

Related Subject Headings

  • Synthetic Biology
  • Genetic Engineering
  • Gene Regulatory Networks
  • Biotechnology
  • 3206 Medical biotechnology
  • 3106 Industrial biotechnology
  • 3001 Agricultural biotechnology
  • 10 Technology
  • 09 Engineering
  • 06 Biological Sciences