Clinical Trials in Melanoma: Margins, Lymph Nodes, Targeted and Immunotherapy.

Journal Article (Journal Article;Review)

Multiple randomized controlled trials have influenced the current standard of care for patients with cutaneous melanoma. Since the development of targeted and immune therapy, studies of adjuvant therapy for patients with resected stage III/IV melanoma have led to the approval of combined B-raf proto-oncogene (BRAF) and mitogen-activated protein kinase kinase inhibitors for patients with a BRAF mutation, and cytotoxic T-lymphocyte associated protein-4 or antiprogrammed cell death-1 therapy for patients without a BRAF mutation. This article discusses the details of the trials that have influenced these treatment decisions, in addition to discussing ongoing trials and possible future directions.

Full Text

Duke Authors

Cited Authors

  • Sharon, CE; Beasley, GM; Karakousis, GC

Published Date

  • January 2023

Published In

Volume / Issue

  • 32 / 1

Start / End Page

  • 47 - 63

PubMed ID

  • 36410921

Electronic International Standard Serial Number (EISSN)

  • 1558-5042

Digital Object Identifier (DOI)

  • 10.1016/j.soc.2022.07.005


  • eng

Conference Location

  • United States