Health-related quality of life impacts upon 5-year survival after coronary artery bypass surgery.

Journal Article (Journal Article)


Poor preoperative health-related quality of life (HRQoL) has been associated with reduced short-term survival after coronary artery bypass graft (CABG) surgery; however, its impact on long-term mortality is unknown. This study's objective was to determine if baseline HRQoL status predicts 5-year post-CABG mortality.


This prespecified, randomized on/off bypass follow-up study (ROOBY-FS) subanalysis compared baseline patient characteristics and HRQoL scores, obtained from the Seattle Angina Questionnaire (SAQ) and Veterans RAND Short Form-36 (VR-36), between 5-year post-CABG survivors and nonsurvivors. Standardized subscores were calculated for each questionnaire. Multivariable logistic regression assessed whether HRQoL survey subcomponents independently predicted 5-year mortality (p ≤ .05).


Of the 2203 ROOBY-FS enrollees, 2104 (95.5%) completed baseline surveys. Significant differences between 5-year post-CABG deaths (n = 286) and survivors (n = 1818) included age, history of chronic obstructive pulmonary disease, stroke, peripheral vascular disease, renal dysfunction, diabetes, lower left ventricular ejection fraction, atrial fibrillation, depression, non-White race/ethnicity, lower education status, and off-pump CABG. Adjusting for these factors, baseline VR-36 physical component summary score (p = .01), VR-36 mental component summary score (p < .001), and SAQ physical limitation score (p = .003) were all associated with 5-year all-cause mortality.


Pre-CABG HRQoL scores may provide clinically relevant prognostic information beyond traditional risk models and prove useful for patient-provider shared decision-making and enhancing pre-CABG informed consent.

Full Text

Duke Authors

Cited Authors

  • Bishawi, M; Hattler, B; Almassi, GH; Quin, JA; Grover, FL; Collins, JF; Ebrahimi, R; Wolbrom, DH; Shroyer, AL; Veterans Affairs Randomized On/Off Bypass Follow-up Study (ROOBY-FS) Group,

Published Date

  • December 2022

Published In

Volume / Issue

  • 37 / 12

Start / End Page

  • 4899 - 4905

PubMed ID

  • 36423254

Electronic International Standard Serial Number (EISSN)

  • 1540-8191

International Standard Serial Number (ISSN)

  • 0886-0440

Digital Object Identifier (DOI)

  • 10.1111/jocs.17165


  • eng