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Platelet Count and Function during Pediatric Extracorporeal Membrane Oxygenation.

Publication ,  Journal Article
Cashen, K; Meert, K; Dalton, HJ
Published in: Semin Thromb Hemost
April 2020

Extracorporeal membrane oxygenation (ECMO) is a form of life support used to treat neonates, children, and adults with cardiorespiratory failure refractory to conventional therapy. This therapy requires the use of anticoagulation to prevent clotting in the extracorporeal circuit, but anticoagulation also increases the risk of bleeding on ECMO. Both bleeding and thrombosis remain significant complications on ECMO and balancing these risks is challenging. Acquired platelet dysfunction is common during ECMO and quantitative and qualitative platelet dysfunction contributes to bleeding risk. Optimal platelet count, function, and transfusion thresholds are not well established during pediatric ECMO. In this review, we provide an overview of hemostatic alterations during ECMO, changes in platelet count and function, platelet monitoring techniques, bleeding risk, and future needs to best optimize patient management and care.

Duke Scholars

Published In

Semin Thromb Hemost

DOI

EISSN

1098-9064

Publication Date

April 2020

Volume

46

Issue

3

Start / End Page

357 / 365

Location

United States

Related Subject Headings

  • Platelet Count
  • Humans
  • Extracorporeal Membrane Oxygenation
  • Cardiovascular System & Hematology
  • Blood Coagulation
  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences
 

Citation

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Cashen, K., Meert, K., & Dalton, H. J. (2020). Platelet Count and Function during Pediatric Extracorporeal Membrane Oxygenation. Semin Thromb Hemost, 46(3), 357–365. https://doi.org/10.1055/s-0040-1708542
Cashen, Katherine, Kathleen Meert, and Heidi J. Dalton. “Platelet Count and Function during Pediatric Extracorporeal Membrane Oxygenation.Semin Thromb Hemost 46, no. 3 (April 2020): 357–65. https://doi.org/10.1055/s-0040-1708542.
Cashen K, Meert K, Dalton HJ. Platelet Count and Function during Pediatric Extracorporeal Membrane Oxygenation. Semin Thromb Hemost. 2020 Apr;46(3):357–65.
Cashen, Katherine, et al. “Platelet Count and Function during Pediatric Extracorporeal Membrane Oxygenation.Semin Thromb Hemost, vol. 46, no. 3, Apr. 2020, pp. 357–65. Pubmed, doi:10.1055/s-0040-1708542.
Cashen K, Meert K, Dalton HJ. Platelet Count and Function during Pediatric Extracorporeal Membrane Oxygenation. Semin Thromb Hemost. 2020 Apr;46(3):357–365.
Journal cover image

Published In

Semin Thromb Hemost

DOI

EISSN

1098-9064

Publication Date

April 2020

Volume

46

Issue

3

Start / End Page

357 / 365

Location

United States

Related Subject Headings

  • Platelet Count
  • Humans
  • Extracorporeal Membrane Oxygenation
  • Cardiovascular System & Hematology
  • Blood Coagulation
  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences