Platelet Count and Function during Pediatric Extracorporeal Membrane Oxygenation.

Journal Article (Journal Article;Review)

Extracorporeal membrane oxygenation (ECMO) is a form of life support used to treat neonates, children, and adults with cardiorespiratory failure refractory to conventional therapy. This therapy requires the use of anticoagulation to prevent clotting in the extracorporeal circuit, but anticoagulation also increases the risk of bleeding on ECMO. Both bleeding and thrombosis remain significant complications on ECMO and balancing these risks is challenging. Acquired platelet dysfunction is common during ECMO and quantitative and qualitative platelet dysfunction contributes to bleeding risk. Optimal platelet count, function, and transfusion thresholds are not well established during pediatric ECMO. In this review, we provide an overview of hemostatic alterations during ECMO, changes in platelet count and function, platelet monitoring techniques, bleeding risk, and future needs to best optimize patient management and care.

Full Text

Duke Authors

Cited Authors

  • Cashen, K; Meert, K; Dalton, HJ

Published Date

  • April 2020

Published In

Volume / Issue

  • 46 / 3

Start / End Page

  • 357 - 365

PubMed ID

  • 32232826

Electronic International Standard Serial Number (EISSN)

  • 1098-9064

Digital Object Identifier (DOI)

  • 10.1055/s-0040-1708542


  • eng

Conference Location

  • United States