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Ten-Year Comparison Study of Type 1 and 2 Endometrial Cancers: Risk Factors and Outcomes.

Publication ,  Journal Article
Feinberg, J; Albright, B; Black, J; Lu, L; Passarelli, R; Gysler, S; Whicker, M; Altwerger, G; Menderes, G; Hui, P; Santin, AD; Azodi, M ...
Published in: Gynecol Obstet Invest
2019

AIMS: To compare baseline risk factors for type 1 vs. 2 endometrial cancers and analyze these risk factors for association with overall survival and time to recurrence. METHODS: Retrospective review of 816 consecutive endometrial cancer cases was conducted with diagnosis from January 2005 to December 2010 and clinical course until 2016. Risk factors, treatment, recurrence, and death were compared using 2 sample t tests, χ2 test and Cox Regression models. RESULTS: There were 550 cases of type 1 and 266 cases of type 2 cancer. Patients with type 2 disease were older (p < 0.001), less obese (p = 0.03), non-white (p < 0.001), and menopausal (p = 0.02). There was no difference in use of oral contraceptives, hormone replacement therapy (HRT), smoking, or major cardiovascular disease. Cox Regression models showed that type 2 disease (p < 0.001) and advanced stage (p = 0.001) were associated with recurrence. CONCLUSIONS: Consistent with previous literature, our analysis found that type 2 cancer is more common in non-white, older, and less obese patients and associated with higher mortality and recurrence. However, inconsistent with previous literature, we found no association between type 2 cancer and diabetes mellitus or use of HRT. These factors should be considered when approaching patients with endometrial cancer.

Duke Scholars

Published In

Gynecol Obstet Invest

DOI

EISSN

1423-002X

Publication Date

2019

Volume

84

Issue

3

Start / End Page

290 / 297

Location

Switzerland

Related Subject Headings

  • Treatment Outcome
  • Risk Factors
  • Retrospective Studies
  • Prognosis
  • Obstetrics & Reproductive Medicine
  • Obesity
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Menopause
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Feinberg, J., Albright, B., Black, J., Lu, L., Passarelli, R., Gysler, S., … Schwartz, P. E. (2019). Ten-Year Comparison Study of Type 1 and 2 Endometrial Cancers: Risk Factors and Outcomes. Gynecol Obstet Invest, 84(3), 290–297. https://doi.org/10.1159/000493132
Feinberg, Jacqueline, Benjamin Albright, Jonathan Black, Lingeng Lu, Rachel Passarelli, Stefan Gysler, Margaret Whicker, et al. “Ten-Year Comparison Study of Type 1 and 2 Endometrial Cancers: Risk Factors and Outcomes.Gynecol Obstet Invest 84, no. 3 (2019): 290–97. https://doi.org/10.1159/000493132.
Feinberg J, Albright B, Black J, Lu L, Passarelli R, Gysler S, et al. Ten-Year Comparison Study of Type 1 and 2 Endometrial Cancers: Risk Factors and Outcomes. Gynecol Obstet Invest. 2019;84(3):290–7.
Feinberg, Jacqueline, et al. “Ten-Year Comparison Study of Type 1 and 2 Endometrial Cancers: Risk Factors and Outcomes.Gynecol Obstet Invest, vol. 84, no. 3, 2019, pp. 290–97. Pubmed, doi:10.1159/000493132.
Feinberg J, Albright B, Black J, Lu L, Passarelli R, Gysler S, Whicker M, Altwerger G, Menderes G, Hui P, Santin AD, Azodi M, Silasi D-A, Ratner ES, Litkouhi B, Schwartz PE. Ten-Year Comparison Study of Type 1 and 2 Endometrial Cancers: Risk Factors and Outcomes. Gynecol Obstet Invest. 2019;84(3):290–297.
Journal cover image

Published In

Gynecol Obstet Invest

DOI

EISSN

1423-002X

Publication Date

2019

Volume

84

Issue

3

Start / End Page

290 / 297

Location

Switzerland

Related Subject Headings

  • Treatment Outcome
  • Risk Factors
  • Retrospective Studies
  • Prognosis
  • Obstetrics & Reproductive Medicine
  • Obesity
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Menopause
  • Humans