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Associated characteristics and impact on recurrence and survival of free-floating tumor fragments in the lumen of fallopian tubes in Type I and Type II endometrial cancer.

Publication ,  Journal Article
Albright, BB; Black, JD; Passarelli, R; Gysler, S; Whicker, M; Altwerger, G; Menderes, G; Buza, N; Hui, P; Santin, AD; Azodi, M; Silasi, D-A ...
Published in: Gynecol Oncol Rep
February 2018

OBJECTIVE: This study sought to evaluate characteristics of cases of free-floating tumor fragments within the lumen of fallopian tubes ('floaters') on final pathology for Type I and Type II endometrial adenocarcinoma, including relationships with disease recurrence and mortality. METHODS: A single institution experience of 1022 consecutive cases of uterine cancer presenting between 2005 and 2010 was retrospectively reviewed, with data extraction from electronic medical records. Associations of floaters with baseline characteristics were studied with logistic regression, and relationships with disease recurrence and survival were assessed with Cox proportional hazards models. RESULTS: Among 816 included cases of Type I or Type II endometrial adenocarcinoma, floaters were identified on final pathology for 20 patients (2.5%). Patient characteristics of cases with floaters mirrored the overall sample. With adjustment, presence of floaters trended towards association with laparoscopic/robotic approach (OR = 3.84; 95%CI 0.98-15.1), and was significantly associated with lymphovascular invasion (OR = 9.65; 95%CI 2.35-39.6) and higher stage disease. Although floaters were associated with increased risk of recurrence in unadjusted analysis (HR = 3.22; 95%CI 1.41-7.37), after adjustment for disease type, stage, and patient comorbidities, no evidence for impact on disease recurrence or overall survival was found. CONCLUSIONS: The presence of floaters is rare. Floaters were generally associated with more extensive disease, but no evidence was found to show any independent prognostic impact on risk of recurrence or death. In agreement with prior research, this study found a trend towards association of floaters with laparoscopic/robotic approach, indicating the possibility of floaters sometimes being the result of trauma from uterine manipulator insertion.

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Published In

Gynecol Oncol Rep

DOI

ISSN

2352-5789

Publication Date

February 2018

Volume

23

Start / End Page

28 / 33

Location

Netherlands
 

Citation

APA
Chicago
ICMJE
MLA
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Albright, B. B., Black, J. D., Passarelli, R., Gysler, S., Whicker, M., Altwerger, G., … Schwartz, P. E. (2018). Associated characteristics and impact on recurrence and survival of free-floating tumor fragments in the lumen of fallopian tubes in Type I and Type II endometrial cancer. Gynecol Oncol Rep, 23, 28–33. https://doi.org/10.1016/j.gore.2018.01.003
Albright, Benjamin B., Jonathan D. Black, Rachel Passarelli, Stefan Gysler, Margaret Whicker, Gary Altwerger, Gulden Menderes, et al. “Associated characteristics and impact on recurrence and survival of free-floating tumor fragments in the lumen of fallopian tubes in Type I and Type II endometrial cancer.Gynecol Oncol Rep 23 (February 2018): 28–33. https://doi.org/10.1016/j.gore.2018.01.003.
Albright BB, Black JD, Passarelli R, Gysler S, Whicker M, Altwerger G, et al. Associated characteristics and impact on recurrence and survival of free-floating tumor fragments in the lumen of fallopian tubes in Type I and Type II endometrial cancer. Gynecol Oncol Rep. 2018 Feb;23:28–33.
Albright, Benjamin B., et al. “Associated characteristics and impact on recurrence and survival of free-floating tumor fragments in the lumen of fallopian tubes in Type I and Type II endometrial cancer.Gynecol Oncol Rep, vol. 23, Feb. 2018, pp. 28–33. Pubmed, doi:10.1016/j.gore.2018.01.003.
Albright BB, Black JD, Passarelli R, Gysler S, Whicker M, Altwerger G, Menderes G, Buza N, Hui P, Santin AD, Azodi M, Silasi D-A, Ratner ES, Litkouhi B, Schwartz PE. Associated characteristics and impact on recurrence and survival of free-floating tumor fragments in the lumen of fallopian tubes in Type I and Type II endometrial cancer. Gynecol Oncol Rep. 2018 Feb;23:28–33.
Journal cover image

Published In

Gynecol Oncol Rep

DOI

ISSN

2352-5789

Publication Date

February 2018

Volume

23

Start / End Page

28 / 33

Location

Netherlands