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Maternal exposure to perfluorobutane sulfonate (PFBS) during pregnancy: evidence of adverse maternal and fetoplacental effects in New Zealand White (NZW) rabbits.

Publication ,  Journal Article
Crute, CE; Landon, CD; Garner, A; Hall, SM; Everitt, JI; Zhang, S; Blake, B; Olofsson, D; Chen, H; Stapleton, HM; Murphy, SK; Feng, L
Published in: Toxicol Sci
February 17, 2023

Perfluorobutanesulfonic acid (PFBS) is a replacement for perfluorooctanesulfonic acid (PFOS) that is increasingly detected in drinking water and human serum. Higher PFBS exposure is associated with risk for preeclampsia, the leading cause of maternal and infant morbidity and mortality in the United States. This study investigated relevant maternal and fetal health outcomes after gestational exposure to PFBS in a New Zealand White rabbit model. Nulliparous female rabbits were supplied drinking water containing 0 mg/l (control), 10 mg/l (low), or 100 mg/l (high) PFBS. Maternal blood pressure, body weights, liver and kidney weights histopathology, clinical chemistry panels, and thyroid hormone levels were evaluated. Fetal endpoints evaluated at necropsy included viability, body weights, crown-rump length, and liver and kidney histopathology, whereas placenta endpoints included weight, morphology, histopathology, and full transcriptome RNA sequencing. PFBS-high dose dams exhibited significant changes in blood pressure markers, seen through increased pulse pressure and renal resistive index measures, as well as kidney histopathological changes. Fetuses from these dams showed decreased crown-rump length. Statistical analysis of placental weight via a mixed model statistical approach identified a significant interaction term between PFBS high dose and fetal sex, suggesting a sex-specific effect on placental weight. RNA sequencing identified the dysregulation of angiotensin (AGT) in PFBS high-dose placentas. These results suggest that PFBS exposure during gestation leads to adverse maternal outcomes, such as renal injury and hypertension, and fetal outcomes, including decreased growth parameters and adverse placenta function. These outcomes raise concerns about pregnant women's exposure to PFBS and pregnancy outcomes.

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Published In

Toxicol Sci

DOI

EISSN

1096-0929

Publication Date

February 17, 2023

Volume

191

Issue

2

Start / End Page

239 / 252

Location

United States

Related Subject Headings

  • Toxicology
  • Rabbits
  • Pregnancy
  • Placenta
  • New Zealand
  • Maternal Exposure
  • Male
  • Humans
  • Fluorocarbons
  • Female
 

Citation

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Crute, C. E., Landon, C. D., Garner, A., Hall, S. M., Everitt, J. I., Zhang, S., … Feng, L. (2023). Maternal exposure to perfluorobutane sulfonate (PFBS) during pregnancy: evidence of adverse maternal and fetoplacental effects in New Zealand White (NZW) rabbits. Toxicol Sci, 191(2), 239–252. https://doi.org/10.1093/toxsci/kfac126
Crute, Christine E., Chelsea D. Landon, Angela Garner, Samantha M. Hall, Jeffery I. Everitt, Sharon Zhang, Bevin Blake, et al. “Maternal exposure to perfluorobutane sulfonate (PFBS) during pregnancy: evidence of adverse maternal and fetoplacental effects in New Zealand White (NZW) rabbits.Toxicol Sci 191, no. 2 (February 17, 2023): 239–52. https://doi.org/10.1093/toxsci/kfac126.
Crute CE, Landon CD, Garner A, Hall SM, Everitt JI, Zhang S, et al. Maternal exposure to perfluorobutane sulfonate (PFBS) during pregnancy: evidence of adverse maternal and fetoplacental effects in New Zealand White (NZW) rabbits. Toxicol Sci. 2023 Feb 17;191(2):239–52.
Crute, Christine E., et al. “Maternal exposure to perfluorobutane sulfonate (PFBS) during pregnancy: evidence of adverse maternal and fetoplacental effects in New Zealand White (NZW) rabbits.Toxicol Sci, vol. 191, no. 2, Feb. 2023, pp. 239–52. Pubmed, doi:10.1093/toxsci/kfac126.
Crute CE, Landon CD, Garner A, Hall SM, Everitt JI, Zhang S, Blake B, Olofsson D, Chen H, Stapleton HM, Murphy SK, Feng L. Maternal exposure to perfluorobutane sulfonate (PFBS) during pregnancy: evidence of adverse maternal and fetoplacental effects in New Zealand White (NZW) rabbits. Toxicol Sci. 2023 Feb 17;191(2):239–252.
Journal cover image

Published In

Toxicol Sci

DOI

EISSN

1096-0929

Publication Date

February 17, 2023

Volume

191

Issue

2

Start / End Page

239 / 252

Location

United States

Related Subject Headings

  • Toxicology
  • Rabbits
  • Pregnancy
  • Placenta
  • New Zealand
  • Maternal Exposure
  • Male
  • Humans
  • Fluorocarbons
  • Female