Pregnancy outcomes after snakebite envenomations: A retrospective cohort in the Brazilian Amazonia.

Journal Article (Journal Article)

Snakebite envenomations (SBEs) in pregnant women can result in adverse maternal or neonatal effects, such as abortion, placental abruption, preterm labor, fetal malformations, and maternal, fetal or neonatal deaths. Despite the high incidence of SBEs in the Brazilian Amazon, there is no literature on the impact of SBEs on pregnancy outcomes. The objective of this study was to describe clinical epidemiology and outcomes associated with SBEs in women of childbearing age and pregnant women in the state of Amazonas, Western Brazilian Amazon, from 2007 to 2021. Information on the population was obtained from the Reporting Information System (SINAN), Mortality Information System (SIM) and Live Birth Information System (SINASC) for the period from 2007 to 2021. A total of 36,786 SBEs were reported, of which 3,297 (9%) involved women of childbearing age, and 274 (8.3%) involved pregnant women. Severity (7.9% in pregnant versus 8.7% in non-pregnant women) (P = 0.87) and case-fatality (0.4% in pregnant versus 0.3% in non-pregnant women) rates were similar between groups (P = 0.76). Pregnant women who suffered snakebites were at higher risk for fetal death (OR: 2.17, 95%CI: 1.74-2.67) and neonatal death (OR = 2.79, 95%CI: 2.26-3.40). This study had major limitations related to the completeness of the information on the pregnancy outcomes. Although SBE incidence in pregnant women is low in the Brazilian Amazon, SBEs increased the risk of fetal and neonatal deaths.

Full Text

Duke Authors

Cited Authors

  • Nascimento, TP; Vilhena Silva-Neto, A; Baia-da-Silva, DC; da Silva Balieiro, PC; Baleiro, AADS; Sachett, J; Brasileiro, L; Sartim, MA; Martinez-Espinosa, FE; Wen, FH; Pucca, MB; Gerardo, CJ; Sampaio, VS; Ferreira de Aquino, P; Monteiro, WM

Published Date

  • December 2022

Published In

Volume / Issue

  • 16 / 12

Start / End Page

  • e0010963 -

PubMed ID

  • 36469516

Pubmed Central ID

  • PMC9754599

Electronic International Standard Serial Number (EISSN)

  • 1935-2735

Digital Object Identifier (DOI)

  • 10.1371/journal.pntd.0010963


  • eng

Conference Location

  • United States