Sound out the impaired perfusion: Photoacoustic imaging in preclinical ischemic stroke.

Journal Article (Review;Journal Article)

Acoustically detecting the optical absorption contrast, photoacoustic imaging (PAI) is a highly versatile imaging modality that can provide anatomical, functional, molecular, and metabolic information of biological tissues. PAI is highly scalable and can probe the same biological process at various length scales ranging from single cells (microscopic) to the whole organ (macroscopic). Using hemoglobin as the endogenous contrast, PAI is capable of label-free imaging of blood vessels in the brain and mapping hemodynamic functions such as blood oxygenation and blood flow. These imaging merits make PAI a great tool for studying ischemic stroke, particularly for probing into hemodynamic changes and impaired cerebral blood perfusion as a consequence of stroke. In this narrative review, we aim to summarize the scientific progresses in the past decade by using PAI to monitor cerebral blood vessel impairment and restoration after ischemic stroke, mostly in the preclinical setting. We also outline and discuss the major technological barriers and challenges that need to be overcome so that PAI can play a more significant role in preclinical stroke research, and more importantly, accelerate its translation to be a useful clinical diagnosis and management tool for human strokes.

Full Text

Duke Authors

Cited Authors

  • Menozzi, L; Yang, W; Feng, W; Yao, J

Published Date

  • January 2022

Published In

Volume / Issue

  • 16 /

Start / End Page

  • 1055552 -

PubMed ID

  • 36532279

Pubmed Central ID

  • PMC9751426

Electronic International Standard Serial Number (EISSN)

  • 1662-453X

International Standard Serial Number (ISSN)

  • 1662-4548

Digital Object Identifier (DOI)

  • 10.3389/fnins.2022.1055552


  • eng