Daphnepedunins A-F, Anti-HIV Macrocyclic Daphnane Orthoester Diterpenoids from Daphne pedunculata.
Publication
, Journal Article
Tan, L; Otsuki, K; Zhang, M; Kikuchi, T; Okayasu, M; Azumaya, I; Zhou, D; Li, N; Huang, L; Chen, C-H; Li, W
Published in: J Nat Prod
December 23, 2022
From the whole plant of Daphne pedunculata, 12 macrocyclic daphnane diterpenoids, including six new compounds, daphnepedunins A-F (1-4, 9, and 10), were isolated. Their structures were elucidated by physiochemical and spectroscopic data analysis, the modified Mosher's method, and X-ray crystallography. The isolated compounds were evaluated for anti-HIV activity against HIV-1 infection in MT4 cells and showed significant anti-HIV activity with IC50 values of 36.3-994 nM. A consideration of the anti-HIV activity of these compounds provided further insight into the structure-activity relationships of macrocyclic daphnane diterpenoids.
Duke Scholars
Published In
J Nat Prod
DOI
EISSN
1520-6025
Publication Date
December 23, 2022
Volume
85
Issue
12
Start / End Page
2856 / 2864
Location
United States
Related Subject Headings
- Thoracica
- Molecular Structure
- Medicinal & Biomolecular Chemistry
- Diterpenes
- Daphne
- Anti-HIV Agents
- Animals
- 4208 Traditional, complementary and integrative medicine
- 11 Medical and Health Sciences
- 06 Biological Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Tan, L., Otsuki, K., Zhang, M., Kikuchi, T., Okayasu, M., Azumaya, I., … Li, W. (2022). Daphnepedunins A-F, Anti-HIV Macrocyclic Daphnane Orthoester Diterpenoids from Daphne pedunculata. J Nat Prod, 85(12), 2856–2864. https://doi.org/10.1021/acs.jnatprod.2c00894
Tan, Lingjian, Kouharu Otsuki, Mi Zhang, Takashi Kikuchi, Misaki Okayasu, Isao Azumaya, Di Zhou, et al. “Daphnepedunins A-F, Anti-HIV Macrocyclic Daphnane Orthoester Diterpenoids from Daphne pedunculata.” J Nat Prod 85, no. 12 (December 23, 2022): 2856–64. https://doi.org/10.1021/acs.jnatprod.2c00894.
Tan L, Otsuki K, Zhang M, Kikuchi T, Okayasu M, Azumaya I, et al. Daphnepedunins A-F, Anti-HIV Macrocyclic Daphnane Orthoester Diterpenoids from Daphne pedunculata. J Nat Prod. 2022 Dec 23;85(12):2856–64.
Tan, Lingjian, et al. “Daphnepedunins A-F, Anti-HIV Macrocyclic Daphnane Orthoester Diterpenoids from Daphne pedunculata.” J Nat Prod, vol. 85, no. 12, Dec. 2022, pp. 2856–64. Pubmed, doi:10.1021/acs.jnatprod.2c00894.
Tan L, Otsuki K, Zhang M, Kikuchi T, Okayasu M, Azumaya I, Zhou D, Li N, Huang L, Chen C-H, Li W. Daphnepedunins A-F, Anti-HIV Macrocyclic Daphnane Orthoester Diterpenoids from Daphne pedunculata. J Nat Prod. 2022 Dec 23;85(12):2856–2864.
Published In
J Nat Prod
DOI
EISSN
1520-6025
Publication Date
December 23, 2022
Volume
85
Issue
12
Start / End Page
2856 / 2864
Location
United States
Related Subject Headings
- Thoracica
- Molecular Structure
- Medicinal & Biomolecular Chemistry
- Diterpenes
- Daphne
- Anti-HIV Agents
- Animals
- 4208 Traditional, complementary and integrative medicine
- 11 Medical and Health Sciences
- 06 Biological Sciences