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The Aging-Cancer Cycle: Mechanisms and Opportunities for Intervention.

Publication ,  Journal Article
Sedrak, MS; Cohen, HJ
Published in: J Gerontol A Biol Sci Med Sci
July 8, 2023

Aging is the largest risk factor for the development of cancer. A growing body of literature indicates that aging and cancer often play a somewhat reciprocal relationship at various times. On the one hand, aging is a "driver" of cancer, and on the other, cancer is a "disease driver" of aging. Here, we synthesize our reflections on the current literature linking cancer and aging, with an eye on fundamental aging processes, such as cellular senescence. Additionally, we consider how interventions that target fundamental aging processes can potentially transform cancer care, from preventing cancer development and progression to reducing the burden of accelerated aging in cancer survivors. Finally, we conclude with a reflection highlighting our vision for future directions to advance the science of cancer and aging and its applicability to improve the care of older adults with cancer.

Duke Scholars

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Published In

J Gerontol A Biol Sci Med Sci

DOI

EISSN

1758-535X

Publication Date

July 8, 2023

Volume

78

Issue

7

Start / End Page

1234 / 1238

Location

United States

Related Subject Headings

  • Risk Factors
  • Neoplasms
  • Humans
  • Gerontology
  • Forecasting
  • Cellular Senescence
  • Aging
  • Aged
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
 

Citation

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Chicago
ICMJE
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Sedrak, M. S., & Cohen, H. J. (2023). The Aging-Cancer Cycle: Mechanisms and Opportunities for Intervention. J Gerontol A Biol Sci Med Sci, 78(7), 1234–1238. https://doi.org/10.1093/gerona/glac247
Sedrak, Mina S., and Harvey Jay Cohen. “The Aging-Cancer Cycle: Mechanisms and Opportunities for Intervention.J Gerontol A Biol Sci Med Sci 78, no. 7 (July 8, 2023): 1234–38. https://doi.org/10.1093/gerona/glac247.
Sedrak MS, Cohen HJ. The Aging-Cancer Cycle: Mechanisms and Opportunities for Intervention. J Gerontol A Biol Sci Med Sci. 2023 Jul 8;78(7):1234–8.
Sedrak, Mina S., and Harvey Jay Cohen. “The Aging-Cancer Cycle: Mechanisms and Opportunities for Intervention.J Gerontol A Biol Sci Med Sci, vol. 78, no. 7, July 2023, pp. 1234–38. Pubmed, doi:10.1093/gerona/glac247.
Sedrak MS, Cohen HJ. The Aging-Cancer Cycle: Mechanisms and Opportunities for Intervention. J Gerontol A Biol Sci Med Sci. 2023 Jul 8;78(7):1234–1238.
Journal cover image

Published In

J Gerontol A Biol Sci Med Sci

DOI

EISSN

1758-535X

Publication Date

July 8, 2023

Volume

78

Issue

7

Start / End Page

1234 / 1238

Location

United States

Related Subject Headings

  • Risk Factors
  • Neoplasms
  • Humans
  • Gerontology
  • Forecasting
  • Cellular Senescence
  • Aging
  • Aged
  • 42 Health sciences
  • 32 Biomedical and clinical sciences