Nitric oxide-releasing silica nanoparticle-doped polyurethane electrospun fibers.

Journal Article (Journal Article)

Electrospun polyurethane fibers doped with nitric oxide (NO)-releasing silica particles are presented as novel macromolecular scaffolds with prolonged NO-release and high porosity. Fiber diameter (119-614 nm) and mechanical strength (1.7-34.5 MPa of modulus) were varied by altering polyurethane type and concentration, as well as the NO-releasing particle composition, size, and concentration. The resulting NO-releasing electrospun nanofibers exhibited ~83% porosity with flexible plastic or elastomeric behavior. The use of N-diazeniumdiolate- or S-nitrosothiol-modified particles yielded scaffolds exhibiting a wide range of NO release totals and durations (7.5 nmol mg(-1)-0.12 μmol mg(-1) and 7 h to 2 weeks, respectively). The application of NO-releasing porous materials as coatings for subcutaneous implants may improve tissue biocompatibility by mitigating the foreign body response and promoting cell integration.

Full Text

Duke Authors

Cited Authors

  • Koh, A; Carpenter, AW; Slomberg, DL; Schoenfisch, MH

Published Date

  • August 2013

Published In

Volume / Issue

  • 5 / 16

Start / End Page

  • 7956 - 7964

PubMed ID

  • 23915047

Pubmed Central ID

  • PMC3811043

Electronic International Standard Serial Number (EISSN)

  • 1944-8252

International Standard Serial Number (ISSN)

  • 1944-8244

Digital Object Identifier (DOI)

  • 10.1021/am402044s


  • eng