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Willingness of Women with Endometriosis Planning to Undergo IVF to Participate in a Randomized Clinical Trial and the Effects of the COVID-19 Pandemic on Potential Participation.

Publication ,  Journal Article
Pretzel, S; Kuhn, K; Pal, L; Polotsky, A; Taylor, HS; Zhang, H; Robins, J; Young, SL; Santoro, N
Published in: Reprod Sci
February 2022

The Pre-IVF Treatment with a GnRH Antagonist in Women with Endometriosis (PREGnant) Trial (clinicaltrials.gov no. NCT04173169) was designed to test the hypothesis that 60-day pre-treatment with an oral GnRH antagonist in women with documented endometriosis and planning an IVF cycle will result in a superior live birth rate to placebo. Eight hundred fourteen women are required from 4 national sites. To determine the feasibility of using an electronic medical record (EMR)-based strategy to recruit 204 participants at the Colorado site, we conducted a survey of women within the UCHealth system. Eligible women, identified using relevant ICD-10 codes, were invited to complete a 6-question survey to assess planned utilization of IVF, potential interest in participation, and whether delays in treatment due to COVID-19 would influence their decision to participate. Of 6354 age-eligible women with an endometriosis diagnosis, 421 had a concurrent infertility diagnosis. After eliminating duplicates, 212 were emailed a survey; 76 (36%) responded, 6 of whom reported no endometriosis diagnosis. Of the remaining 70, 29 (41%) were planning fertility treatment; only 19 planned IVF. All 19 expressed interest in participation. COVID-19 delays in treatment were not considered as a factor affecting participation by 8/19; the remaining 11 felt that it would "somewhat" affect their decision. None reported that they would not consider participation because of COVID-19. EMR-based recruitment for an endometriosis clinical trial is feasible although the overall yield of participants is low. Delays in treatment due to COVID-19 did not appear to overly influence potential recruitment.

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Published In

Reprod Sci

DOI

EISSN

1933-7205

Publication Date

February 2022

Volume

29

Issue

2

Start / End Page

620 / 626

Location

United States

Related Subject Headings

  • Young Adult
  • United States
  • Treatment Outcome
  • Research Subjects
  • Pregnancy Rate
  • Pregnancy
  • Patient Selection
  • Obstetrics & Reproductive Medicine
  • Live Birth
  • Infertility, Female
 

Citation

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Pretzel, S., Kuhn, K., Pal, L., Polotsky, A., Taylor, H. S., Zhang, H., … Santoro, N. (2022). Willingness of Women with Endometriosis Planning to Undergo IVF to Participate in a Randomized Clinical Trial and the Effects of the COVID-19 Pandemic on Potential Participation. Reprod Sci, 29(2), 620–626. https://doi.org/10.1007/s43032-021-00705-0
Pretzel, Shannon, Katherine Kuhn, Lubna Pal, Alex Polotsky, Hugh S. Taylor, Heping Zhang, Jared Robins, Steven L. Young, and Nanette Santoro. “Willingness of Women with Endometriosis Planning to Undergo IVF to Participate in a Randomized Clinical Trial and the Effects of the COVID-19 Pandemic on Potential Participation.Reprod Sci 29, no. 2 (February 2022): 620–26. https://doi.org/10.1007/s43032-021-00705-0.
Pretzel, Shannon, et al. “Willingness of Women with Endometriosis Planning to Undergo IVF to Participate in a Randomized Clinical Trial and the Effects of the COVID-19 Pandemic on Potential Participation.Reprod Sci, vol. 29, no. 2, Feb. 2022, pp. 620–26. Pubmed, doi:10.1007/s43032-021-00705-0.
Pretzel S, Kuhn K, Pal L, Polotsky A, Taylor HS, Zhang H, Robins J, Young SL, Santoro N. Willingness of Women with Endometriosis Planning to Undergo IVF to Participate in a Randomized Clinical Trial and the Effects of the COVID-19 Pandemic on Potential Participation. Reprod Sci. 2022 Feb;29(2):620–626.
Journal cover image

Published In

Reprod Sci

DOI

EISSN

1933-7205

Publication Date

February 2022

Volume

29

Issue

2

Start / End Page

620 / 626

Location

United States

Related Subject Headings

  • Young Adult
  • United States
  • Treatment Outcome
  • Research Subjects
  • Pregnancy Rate
  • Pregnancy
  • Patient Selection
  • Obstetrics & Reproductive Medicine
  • Live Birth
  • Infertility, Female