Endometrial receptivity: lessons from systems biology and candidate gene studies of endometriosis.

Journal Article (Journal Article;Review)

Endometrial receptivity is essential for embryo implantation and ongoing successful pregnancy. The temporal "window" during which the endometrium allows implantation, known as window of implantation (WOI), which is, characterized alteration of many genes. Transcriptomic changes at the time of implantation let us discover many genes and their protein products whose altered expression effects endometrial receptivity. New omics technologies helped us to understand the complex dynamics of endometrium. Progesterone is responsible for decidualization and establishment of implantation. In women with endometriosis progesterone resistance might impair decidualization and subsequent implantation in different ways. We summarized the effects of progesterone resistance on genes, transcription factors, proteins and inflammatory mediators. Understanding the effects of progesterone resistance on genes and downstream targets will highlight future treatments in patients with endometriosis.

Full Text

Duke Authors

Cited Authors

  • Mathyk, B; Adams, N; Young, SL

Published Date

  • February 2017

Published In

Volume / Issue

  • 69 / 1

Start / End Page

  • 41 - 56

PubMed ID

  • 27576850

Electronic International Standard Serial Number (EISSN)

  • 1827-1650

Digital Object Identifier (DOI)

  • 10.23736/S0026-4784.16.03975-7


  • eng

Conference Location

  • Italy