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Endometrial receptivity: lessons from systems biology and candidate gene studies of endometriosis.

Publication ,  Journal Article
Mathyk, B; Adams, N; Young, SL
Published in: Minerva Ginecol
February 2017

Endometrial receptivity is essential for embryo implantation and ongoing successful pregnancy. The temporal "window" during which the endometrium allows implantation, known as window of implantation (WOI), which is, characterized alteration of many genes. Transcriptomic changes at the time of implantation let us discover many genes and their protein products whose altered expression effects endometrial receptivity. New omics technologies helped us to understand the complex dynamics of endometrium. Progesterone is responsible for decidualization and establishment of implantation. In women with endometriosis progesterone resistance might impair decidualization and subsequent implantation in different ways. We summarized the effects of progesterone resistance on genes, transcription factors, proteins and inflammatory mediators. Understanding the effects of progesterone resistance on genes and downstream targets will highlight future treatments in patients with endometriosis.

Duke Scholars

Published In

Minerva Ginecol

DOI

EISSN

1827-1650

Publication Date

February 2017

Volume

69

Issue

1

Start / End Page

41 / 56

Location

Italy

Related Subject Headings

  • Uterine Diseases
  • Transcriptome
  • Transcription Factors
  • Systems Biology
  • Progesterone
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Inflammation Mediators
  • Humans
  • Female
 

Citation

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Chicago
ICMJE
MLA
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Mathyk, B., Adams, N., & Young, S. L. (2017). Endometrial receptivity: lessons from systems biology and candidate gene studies of endometriosis. Minerva Ginecol, 69(1), 41–56. https://doi.org/10.23736/S0026-4784.16.03975-7
Mathyk, Begum, Nyssa Adams, and Steven L. Young. “Endometrial receptivity: lessons from systems biology and candidate gene studies of endometriosis.Minerva Ginecol 69, no. 1 (February 2017): 41–56. https://doi.org/10.23736/S0026-4784.16.03975-7.
Mathyk B, Adams N, Young SL. Endometrial receptivity: lessons from systems biology and candidate gene studies of endometriosis. Minerva Ginecol. 2017 Feb;69(1):41–56.
Mathyk, Begum, et al. “Endometrial receptivity: lessons from systems biology and candidate gene studies of endometriosis.Minerva Ginecol, vol. 69, no. 1, Feb. 2017, pp. 41–56. Pubmed, doi:10.23736/S0026-4784.16.03975-7.
Mathyk B, Adams N, Young SL. Endometrial receptivity: lessons from systems biology and candidate gene studies of endometriosis. Minerva Ginecol. 2017 Feb;69(1):41–56.

Published In

Minerva Ginecol

DOI

EISSN

1827-1650

Publication Date

February 2017

Volume

69

Issue

1

Start / End Page

41 / 56

Location

Italy

Related Subject Headings

  • Uterine Diseases
  • Transcriptome
  • Transcription Factors
  • Systems Biology
  • Progesterone
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Inflammation Mediators
  • Humans
  • Female