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AMH in women with diminished ovarian reserve: potential differences by FMR1 CGG repeat level.

Publication ,  Journal Article
Pastore, LM; McMurry, TL; Williams, CD; Baker, VL; Young, SL
Published in: J Assist Reprod Genet
October 2014

PURPOSE: We explored whether AMH, as a surrogate for oocyte supply, varies by FMR1 genotype in women diagnosed with diminished ovarian reserve (DOR), a subset of the Primary Ovarian Insufficiency phenotype. Research is inconsistent on the relationship between AMH and FMR1 repeat length, controlling for age. METHOD: Seventy-nine cycling women diagnosed with DOR, and without a family history of fragile X syndrome, provided blood for FMR1 and AMH testing. DOR was defined as elevated FSH and/or low AMH and/or low antral follicle count, with regular menses. FMR1 CGG repeats were stratified by the larger allele <35 repeats (n = 70) v. ≥35 repeats (n = 9). Quadratic and linear models were fit to predict log (AMH) controlling for age. The AMH sample used as the outcome variable was drawn at a later date than the diagnostic AMH. RESULTS: Serum AMH concentration median was 0.30 ng/mL; Ages ranged from 26-43 years. A quadratic model (including age(2)) did not show a relationship with FMR1 CGG level (p-value = 0.25). A linear model of log (AMH), corresponding to an exponential decline of AMH with increasing age, was significantly different, and had a steeper slope, for women with ≥ 35 CGG repeats than women with < 35 repeats (p = 0.035). CONCLUSION: Findings suggest a greater rate of follicular loss that starts at later ages in women with DOR and ≥ 35 CGG repeats.

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Published In

J Assist Reprod Genet

DOI

EISSN

1573-7330

Publication Date

October 2014

Volume

31

Issue

10

Start / End Page

1295 / 1301

Location

Netherlands

Related Subject Headings

  • Trinucleotide Repeat Expansion
  • Primary Ovarian Insufficiency
  • Ovary
  • Ovarian Reserve
  • Oocytes
  • Obstetrics & Reproductive Medicine
  • Humans
  • Genotype
  • Fragile X Syndrome
  • Fragile X Mental Retardation Protein
 

Citation

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Pastore, L. M., McMurry, T. L., Williams, C. D., Baker, V. L., & Young, S. L. (2014). AMH in women with diminished ovarian reserve: potential differences by FMR1 CGG repeat level. J Assist Reprod Genet, 31(10), 1295–1301. https://doi.org/10.1007/s10815-014-0276-2
Pastore, Lisa M., Timothy L. McMurry, Christopher D. Williams, Valerie L. Baker, and Steven L. Young. “AMH in women with diminished ovarian reserve: potential differences by FMR1 CGG repeat level.J Assist Reprod Genet 31, no. 10 (October 2014): 1295–1301. https://doi.org/10.1007/s10815-014-0276-2.
Pastore LM, McMurry TL, Williams CD, Baker VL, Young SL. AMH in women with diminished ovarian reserve: potential differences by FMR1 CGG repeat level. J Assist Reprod Genet. 2014 Oct;31(10):1295–301.
Pastore, Lisa M., et al. “AMH in women with diminished ovarian reserve: potential differences by FMR1 CGG repeat level.J Assist Reprod Genet, vol. 31, no. 10, Oct. 2014, pp. 1295–301. Pubmed, doi:10.1007/s10815-014-0276-2.
Pastore LM, McMurry TL, Williams CD, Baker VL, Young SL. AMH in women with diminished ovarian reserve: potential differences by FMR1 CGG repeat level. J Assist Reprod Genet. 2014 Oct;31(10):1295–1301.
Journal cover image

Published In

J Assist Reprod Genet

DOI

EISSN

1573-7330

Publication Date

October 2014

Volume

31

Issue

10

Start / End Page

1295 / 1301

Location

Netherlands

Related Subject Headings

  • Trinucleotide Repeat Expansion
  • Primary Ovarian Insufficiency
  • Ovary
  • Ovarian Reserve
  • Oocytes
  • Obstetrics & Reproductive Medicine
  • Humans
  • Genotype
  • Fragile X Syndrome
  • Fragile X Mental Retardation Protein