The Mutation Profile of SARS-CoV-2 Is Primarily Shaped by the Host Antiviral Defense.

Journal Article (Journal Article)

Understanding SARS-CoV-2 evolution is a fundamental effort in coping with the COVID-19 pandemic. The virus genomes have been broadly evolving due to the high number of infected hosts world-wide. Mutagenesis and selection are two inter-dependent mechanisms of virus diversification. However, which mechanisms contribute to the mutation profiles of SARS-CoV-2 remain under-explored. Here, we delineate the contribution of mutagenesis and selection to the genome diversity of SARS-CoV-2 isolates. We generated a comprehensive phylogenetic tree with representative genomes. Instead of counting mutations relative to the reference genome, we identified each mutation event at the nodes of the phylogenetic tree. With this approach, we obtained the mutation events that are independent of each other and generated the mutation profile of SARS-CoV-2 genomes. The results suggest that the heterogeneous mutation patterns are mainly reflections of host (i) antiviral mechanisms that are achieved through APOBEC, ADAR, and ZAP proteins, and (ii) probable adaptation against reactive oxygen species.

Full Text

Duke Authors

Cited Authors

  • Azgari, C; Kilinc, Z; Turhan, B; Circi, D; Adebali, O

Published Date

  • March 2021

Published In

Volume / Issue

  • 13 / 3

Start / End Page

  • 394 -

PubMed ID

  • 33801257

Pubmed Central ID

  • PMC7999997

Electronic International Standard Serial Number (EISSN)

  • 1999-4915

International Standard Serial Number (ISSN)

  • 1999-4915

Digital Object Identifier (DOI)

  • 10.3390/v13030394

Language

  • eng