Solution NMR studies of the plant peptide hormone CEP inform function.

Journal Article (Journal Article)

The C-terminally Encoded Peptide (CEP) family of regulatory peptides controls root development in vascular plants. Here, we present the first NMR structures of CEP. We show that root-knot nematode (RKN: Meloidogyne spp.) also encodes CEP, presumably to mimic plant CEP as part of their stereotypic, parasitic interaction with vascular plants. Molecular dynamics simulations of plant- and nematode-encoded CEP displaying known posttranslational modifications (PTM) provided insight into the structural effects of PTM and the conformational plasticity and rigidity of CEP. Potential mechanisms of action are discussed with respect to the structure and sampling of conformational space.

Full Text

Duke Authors

Cited Authors

  • Bobay, BG; DiGennaro, P; Scholl, E; Imin, N; Djordjevic, MA; Mck Bird, D

Published Date

  • December 2013

Published In

Volume / Issue

  • 587 / 24

Start / End Page

  • 3979 - 3985

PubMed ID

  • 24211833

Electronic International Standard Serial Number (EISSN)

  • 1873-3468

International Standard Serial Number (ISSN)

  • 0014-5793

Digital Object Identifier (DOI)

  • 10.1016/j.febslet.2013.10.033


  • eng