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Circulating microparticle proteins predict pregnancies complicated by placenta accreta spectrum.

Publication ,  Journal Article
Yu, HY; Gumusoglu, SB; Cantonwine, DE; Carusi, DA; Gurnani, P; Schickling, B; Doss, RC; Santillan, MK; Rosenblatt, KP; McElrath, TF
Published in: Sci Rep
January 5, 2023

Placenta accreta spectrum (PAS) is characterized by abnormal attachment of the placenta to the uterus, and attempts at placental delivery can lead to catastrophic maternal hemorrhage and death. Multidisciplinary delivery planning can significantly improve outcomes; however, current diagnostics are lacking as approximately half of pregnancies with PAS are undiagnosed prior to delivery. This is a nested case-control study of 35 cases and 70 controls with the primary objective of identifying circulating microparticle (CMP) protein panels that identify pregnancies complicated by PAS. Size exclusion chromatography and liquid chromatography with tandem mass spectrometry were used for CMP protein isolation and identification, respectively. A two-step iterative workflow was used to establish putative panels. Using plasma sampled at a median of 26 weeks' gestation, five CMP proteins distinguished PAS from controls with a mean area under the curve (AUC) of 0.83. For a separate sample taken at a median of 35 weeks' gestation, the mean AUC was 0.78. In the second trimester, canonical pathway analyses demonstrate over-representation of processes related to iron homeostasis and erythropoietin signaling. In the third trimester, these analyses revealed abnormal immune function. CMP proteins classify PAS well prior to delivery and have potential to significantly reduce maternal morbidity and mortality.

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Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

January 5, 2023

Volume

12

Issue

1

Start / End Page

21922

Location

England

Related Subject Headings

  • Retrospective Studies
  • Pregnancy Trimester, Third
  • Pregnancy
  • Placenta Previa
  • Placenta Accreta
  • Placenta
  • Humans
  • Female
  • Case-Control Studies
 

Citation

APA
Chicago
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MLA
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Yu, H. Y., Gumusoglu, S. B., Cantonwine, D. E., Carusi, D. A., Gurnani, P., Schickling, B., … McElrath, T. F. (2023). Circulating microparticle proteins predict pregnancies complicated by placenta accreta spectrum. Sci Rep, 12(1), 21922. https://doi.org/10.1038/s41598-022-24869-0
Yu, Hope Y., Serena B. Gumusoglu, David E. Cantonwine, Daniela A. Carusi, Prem Gurnani, Brandon Schickling, Robert C. Doss, Mark K. Santillan, Kevin P. Rosenblatt, and Thomas F. McElrath. “Circulating microparticle proteins predict pregnancies complicated by placenta accreta spectrum.Sci Rep 12, no. 1 (January 5, 2023): 21922. https://doi.org/10.1038/s41598-022-24869-0.
Yu HY, Gumusoglu SB, Cantonwine DE, Carusi DA, Gurnani P, Schickling B, et al. Circulating microparticle proteins predict pregnancies complicated by placenta accreta spectrum. Sci Rep. 2023 Jan 5;12(1):21922.
Yu, Hope Y., et al. “Circulating microparticle proteins predict pregnancies complicated by placenta accreta spectrum.Sci Rep, vol. 12, no. 1, Jan. 2023, p. 21922. Pubmed, doi:10.1038/s41598-022-24869-0.
Yu HY, Gumusoglu SB, Cantonwine DE, Carusi DA, Gurnani P, Schickling B, Doss RC, Santillan MK, Rosenblatt KP, McElrath TF. Circulating microparticle proteins predict pregnancies complicated by placenta accreta spectrum. Sci Rep. 2023 Jan 5;12(1):21922.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

January 5, 2023

Volume

12

Issue

1

Start / End Page

21922

Location

England

Related Subject Headings

  • Retrospective Studies
  • Pregnancy Trimester, Third
  • Pregnancy
  • Placenta Previa
  • Placenta Accreta
  • Placenta
  • Humans
  • Female
  • Case-Control Studies