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Changes in resting state networks in high school football athletes across a single season.

Publication ,  Journal Article
Ghiles, CW; Clark, MD; Kuzminski, SJ; Fraser, MA; Petrella, JR; Guskiewicz, KM
Published in: Br J Radiol
March 1, 2023

OBJECTIVE: The aim of this pilot cohort study was to examine changes in the organization of resting-state brain networks in high school football athletes and its relationship to exposure to on-field head impacts over the course of a single season. METHODS: Seventeen male high school football players underwent functional magnetic resonance imaging and computerized neurocognitive testing (CNS Vital Signs) before the start of contact practices and again after the conclusion of the season. The players were equipped with helmet accelerometer systems (Head Impact Telemetry System) to record head impacts in practices and games. Graph theory analysis was applied to study intranetwork local efficiency and strength of connectivity within six anatomically defined brain networks. RESULTS: We observed a significant decrease in the local efficiency (-24.9 ± 51.4%, r = 0.7, p < 0.01) and strength (-14.5 ± 26.8%, r = 0.5, p < 0.01) of functional connectivity within the frontal lobe resting-state network and strength within the parietal lobe resting-state network (-7.5 ± 17.3%, r = 0.1, p < 0.01), as well as a concomitant increase in the local efficiency (+55.0 +/- 59.8%, r = 0.5, p < 0.01) and strength (+47.4 +/- 47.3%, r = 0.5, p < 0.01) within the mediotemporal networks. These alterations in network organization were associated with changes in performance on verbal memory (p < 0.05) and executive function (p < 0.05). We did not observe a significant relationship between the frequency or cumulative magnitude of impacts sustained during the season and neurocognitive or imaging outcomes (p > 0.05). CONCLUSION: Our findings suggest the efficiency and strength of resting-state networks are altered across a season of high school football, but the association of exposure levels to subconcussive impacts is unclear. ADVANCES IN KNOWLEDGE: The efficiency of resting-state networks is dynamic in high school football athletes; such changes may be related to impacts sustained during the season, though further study is needed.

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Published In

Br J Radiol

DOI

EISSN

1748-880X

Publication Date

March 1, 2023

Volume

96

Issue

1144

Start / End Page

20220359

Location

England

Related Subject Headings

  • Seasons
  • Schools
  • Pilot Projects
  • Nuclear Medicine & Medical Imaging
  • Male
  • Humans
  • Football
  • Brain Concussion
  • Athletes
  • 3211 Oncology and carcinogenesis
 

Citation

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Ghiles, C. W., Clark, M. D., Kuzminski, S. J., Fraser, M. A., Petrella, J. R., & Guskiewicz, K. M. (2023). Changes in resting state networks in high school football athletes across a single season. Br J Radiol, 96(1144), 20220359. https://doi.org/10.1259/bjr.20220359
Ghiles, Connor W., Michael D. Clark, Samuel J. Kuzminski, Melissa A. Fraser, Jeffrey R. Petrella, and Kevin M. Guskiewicz. “Changes in resting state networks in high school football athletes across a single season.Br J Radiol 96, no. 1144 (March 1, 2023): 20220359. https://doi.org/10.1259/bjr.20220359.
Ghiles CW, Clark MD, Kuzminski SJ, Fraser MA, Petrella JR, Guskiewicz KM. Changes in resting state networks in high school football athletes across a single season. Br J Radiol. 2023 Mar 1;96(1144):20220359.
Ghiles, Connor W., et al. “Changes in resting state networks in high school football athletes across a single season.Br J Radiol, vol. 96, no. 1144, Mar. 2023, p. 20220359. Pubmed, doi:10.1259/bjr.20220359.
Ghiles CW, Clark MD, Kuzminski SJ, Fraser MA, Petrella JR, Guskiewicz KM. Changes in resting state networks in high school football athletes across a single season. Br J Radiol. 2023 Mar 1;96(1144):20220359.

Published In

Br J Radiol

DOI

EISSN

1748-880X

Publication Date

March 1, 2023

Volume

96

Issue

1144

Start / End Page

20220359

Location

England

Related Subject Headings

  • Seasons
  • Schools
  • Pilot Projects
  • Nuclear Medicine & Medical Imaging
  • Male
  • Humans
  • Football
  • Brain Concussion
  • Athletes
  • 3211 Oncology and carcinogenesis