Skip to main content

Prospective Randomized Control Pilot Study to Compare the Role of Injection Cerebrolysin in Operated cases of Degenerative Cervical Myelopathy.

Publication ,  Journal Article
Sharma, A; Marathe, N; Aggarwal, R; Singh, V; Shakya, A; Kamble, P; Jaiswal, A; Mangale, N; Rocos, B
Published in: Spine (Phila Pa 1976)
January 15, 2022

STUDY DESIGN: Prospective randomized control trial. OBJECTIVE: The aim of this study was to analyze role of cerebrolysin in patients of degenerative cervical myelopathy (DCM) managed by surgical modalities. SUMMARY OF BACKGROUND DATA: Cerebrolysin has been extensively researched with variable success in neurodegenerative pathologies. There has been only one study in published literature till date that has studied role of cerebrolysin in DCM in conservatively managed patients but none in the patients treated surgically. We present our pilot study which analyzes the role of cerebrolysin in patients of DCM managed by surgical modalities. METHODS: This prospective randomized control trial was conducted at a tertiary care institute in Mumbai. Sixty operated cases of DCM were randomly divided into 2 groups. The first group was given Injection Cerebrolysin 5 mL diluted in 100 mL Normal Saline over 30 minutes once a day for 21 days postoperatively. The second group was given placebo. Modified Japanese Orthopedic Association scores (mJOA) and visual analog scale (VAS) were used to document functional outcomes at 3 weeks, 3 months, 6 months, and 1 year. Recovery of hand function was separately accessed by improvement in hand power and sensations. RESULTS: Preoperative mJOA and VAS scores were comparable between 2 groups. Both groups showed significant improvement in both mJOA and VAS scores at 3weeks, 3 months, 6 months and 1-year follow-up (P < 0.01). In comparing the two groups, there was no difference in improvement of mJOA and VAS scores. However, cerebrolysin group showed significant improvement in hand function at 1 year compared to the placebo. Postoperative neurological recovery was better in the cerebrolysin group with 66.7% patients showing complete neurological recovery compared to 56.7% for placebo, but this was statistically insignificant. Two patients developed headache and one patient complained of dizziness in the cerebrolysin group, but these resolved without any intervention. CONCLUSION: Use of cerebrolysin in postoperative cases of DCM is safe and results in improved hand function.Level of Evidence: 1.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Spine (Phila Pa 1976)

DOI

EISSN

1528-1159

Publication Date

January 15, 2022

Volume

47

Issue

2

Start / End Page

E58 / E63

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Spinal Cord Diseases
  • Prospective Studies
  • Pilot Projects
  • Orthopedics
  • Humans
  • Amino Acids
  • 4201 Allied health and rehabilitation science
  • 3209 Neurosciences
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sharma, A., Marathe, N., Aggarwal, R., Singh, V., Shakya, A., Kamble, P., … Rocos, B. (2022). Prospective Randomized Control Pilot Study to Compare the Role of Injection Cerebrolysin in Operated cases of Degenerative Cervical Myelopathy. Spine (Phila Pa 1976), 47(2), E58–E63. https://doi.org/10.1097/BRS.0000000000004131
Sharma, Ayush, Nandan Marathe, Romit Aggarwal, Vijay Singh, Akash Shakya, Prashant Kamble, Ajay Jaiswal, Nilesh Mangale, and Brett Rocos. “Prospective Randomized Control Pilot Study to Compare the Role of Injection Cerebrolysin in Operated cases of Degenerative Cervical Myelopathy.Spine (Phila Pa 1976) 47, no. 2 (January 15, 2022): E58–63. https://doi.org/10.1097/BRS.0000000000004131.
Sharma A, Marathe N, Aggarwal R, Singh V, Shakya A, Kamble P, et al. Prospective Randomized Control Pilot Study to Compare the Role of Injection Cerebrolysin in Operated cases of Degenerative Cervical Myelopathy. Spine (Phila Pa 1976). 2022 Jan 15;47(2):E58–63.
Sharma, Ayush, et al. “Prospective Randomized Control Pilot Study to Compare the Role of Injection Cerebrolysin in Operated cases of Degenerative Cervical Myelopathy.Spine (Phila Pa 1976), vol. 47, no. 2, Jan. 2022, pp. E58–63. Pubmed, doi:10.1097/BRS.0000000000004131.
Sharma A, Marathe N, Aggarwal R, Singh V, Shakya A, Kamble P, Jaiswal A, Mangale N, Rocos B. Prospective Randomized Control Pilot Study to Compare the Role of Injection Cerebrolysin in Operated cases of Degenerative Cervical Myelopathy. Spine (Phila Pa 1976). 2022 Jan 15;47(2):E58–E63.

Published In

Spine (Phila Pa 1976)

DOI

EISSN

1528-1159

Publication Date

January 15, 2022

Volume

47

Issue

2

Start / End Page

E58 / E63

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Spinal Cord Diseases
  • Prospective Studies
  • Pilot Projects
  • Orthopedics
  • Humans
  • Amino Acids
  • 4201 Allied health and rehabilitation science
  • 3209 Neurosciences
  • 3202 Clinical sciences