Type-2 Diabetes, Pancreatic Amylin, and Neuronal Metabolic Remodeling in Alzheimer's Disease.
Type-2 diabetes raises the risk for Alzheimer's disease (AD)-type dementia and the conversion from mild cognitive impairment to dementia, yet mechanisms connecting type-2 diabetes to AD remain largely unknown. Amylin, a pancreatic β-cell hormone co-secreted with insulin, participates in the central regulation of satiation, but also forms pancreatic amyloid in persons with type-2 diabetes and synergistically interacts with brain amyloid β (Aβ) pathology, in both sporadic and familial Alzheimer's disease (AD). Growing evidence from studies of tumor growth, together with early observations in skeletal muscle, indicates amylin as a potential trigger of cellular metabolic reprogramming. Because the blood, cerebrospinal fluid, and brain parenchyma in humans with AD have increased concentrations of amylin, amylin-mediated pathological processes in the brain may involve neuronal metabolic remodeling. This review summarizes recent progress in understanding the link between prediabetic hypersecretion of amylin and risk of neuronal metabolic remodeling and AD and suggests nutritional and medical effects of food constituents that might prevent and/or ameliorate amylin-mediated neuronal metabolic remodeling.
Duke Scholars
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- Nutrition & Dietetics
- Food Science
- 3210 Nutrition and dietetics
- 3006 Food sciences
- 1117 Public Health and Health Services
- 1111 Nutrition and Dietetics
- 0908 Food Sciences
Citation
Published In
DOI
EISSN
Publication Date
Start / End Page
Location
Related Subject Headings
- Nutrition & Dietetics
- Food Science
- 3210 Nutrition and dietetics
- 3006 Food sciences
- 1117 Public Health and Health Services
- 1111 Nutrition and Dietetics
- 0908 Food Sciences