Concise Review: Modulating Cancer Immunity with Hematopoietic Stem and Progenitor Cells.

Journal Article (Review;Journal Article)

Hematopoietic stem and progenitor cells (HSPCs) are the progenitor cells that can regenerate the entire blood compartment, including the immune system. Recent studies have unearthed considerable immune-modulating potential of these cells. They can migrate through chemotactic gradients, differentiate into functional immune cells, and crosstalk with immune cells during infections, autoimmune diseases, and cancers. Although the primary role of HSPCs during solid malignancies is considered immunosuppressive, recent studies have discovered immune-activating HSPCs and progeny. In this review, we will discuss the recent evidence that HSPCs act as immunomodulators during solid cancers and highlight the future directions of discovery. Stem Cells 2019;37:166-175.

Full Text

Duke Authors

Cited Authors

  • Wildes, TJ; Flores, CT; Mitchell, DA

Published Date

  • February 2019

Published In

Volume / Issue

  • 37 / 2

Start / End Page

  • 166 - 175

PubMed ID

  • 30353618

Pubmed Central ID

  • PMC6368859

Electronic International Standard Serial Number (EISSN)

  • 1549-4918

International Standard Serial Number (ISSN)

  • 1066-5099

Digital Object Identifier (DOI)

  • 10.1002/stem.2933


  • eng