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Serum cleaved tau does not predict postconcussion syndrome after mild traumatic brain injury.

Publication ,  Journal Article
Ma, M; Lindsell, CJ; Rosenberry, CM; Shaw, GJ; Zemlan, FP
Published in: Am J Emerg Med
September 2008

OBJECTIVES: Our objective was to determine if the biomarker for axonal injury, serum cleaved tau (C-tau), predicts postconcussion syndrome (PCS) in adults after mild traumatic brain injury (mTBI). METHODS: C-tau was measured from blood obtained in the emergency department. Outcome was assessed at 3 months post injury using the Rivermead Postconcussion Symptoms Questionnaire and Acute Medical Outcomes SF-36v2 Health Survey (SF-36). RESULTS: Of 50 patients, there were 15 patients with detectable levels of C-tau, 10 patients with abnormal findings on initial head computed tomography (CT) and 22 patients with PCS. One-third of patients with detectable C-tau and 14.3% of patients without detectable C-tau had abnormal findings on head CT (P = .143). Serum C-tau was not detected more frequently in patients with PCS than those without, neither for all patients (P = .115) nor the subgroup with negative head CT (P = .253). CONCLUSIONS: C-tau is a poor predictor of PCS after mTBI regardless of head CT result.

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Published In

Am J Emerg Med

DOI

EISSN

1532-8171

Publication Date

September 2008

Volume

26

Issue

7

Start / End Page

763 / 768

Location

United States

Related Subject Headings

  • tau Proteins
  • Trauma Centers
  • Prospective Studies
  • Predictive Value of Tests
  • Post-Concussion Syndrome
  • Male
  • Injury Severity Score
  • Humans
  • Glasgow Coma Scale
  • Female
 

Citation

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Chicago
ICMJE
MLA
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Ma, M., Lindsell, C. J., Rosenberry, C. M., Shaw, G. J., & Zemlan, F. P. (2008). Serum cleaved tau does not predict postconcussion syndrome after mild traumatic brain injury. Am J Emerg Med, 26(7), 763–768. https://doi.org/10.1016/j.ajem.2007.10.029
Ma, Marek, Christopher J. Lindsell, Clark M. Rosenberry, George J. Shaw, and Frank P. Zemlan. “Serum cleaved tau does not predict postconcussion syndrome after mild traumatic brain injury.Am J Emerg Med 26, no. 7 (September 2008): 763–68. https://doi.org/10.1016/j.ajem.2007.10.029.
Ma M, Lindsell CJ, Rosenberry CM, Shaw GJ, Zemlan FP. Serum cleaved tau does not predict postconcussion syndrome after mild traumatic brain injury. Am J Emerg Med. 2008 Sep;26(7):763–8.
Ma, Marek, et al. “Serum cleaved tau does not predict postconcussion syndrome after mild traumatic brain injury.Am J Emerg Med, vol. 26, no. 7, Sept. 2008, pp. 763–68. Pubmed, doi:10.1016/j.ajem.2007.10.029.
Ma M, Lindsell CJ, Rosenberry CM, Shaw GJ, Zemlan FP. Serum cleaved tau does not predict postconcussion syndrome after mild traumatic brain injury. Am J Emerg Med. 2008 Sep;26(7):763–768.
Journal cover image

Published In

Am J Emerg Med

DOI

EISSN

1532-8171

Publication Date

September 2008

Volume

26

Issue

7

Start / End Page

763 / 768

Location

United States

Related Subject Headings

  • tau Proteins
  • Trauma Centers
  • Prospective Studies
  • Predictive Value of Tests
  • Post-Concussion Syndrome
  • Male
  • Injury Severity Score
  • Humans
  • Glasgow Coma Scale
  • Female